Structure via PubChem · Public domain (PubChem)
AFDX384
Sign in to saveAlso known as AF-DX 384, AFDX-384
AFDX-384 (BIBN-161) is a drug which acts as a selective antagonist of the muscarinic acetylcholine receptors, with selectivity for the M2 and M4 subtypes. It is used mainly for mapping the distribution of M2 and M4 muscarinic receptors in the brain, and studying their involvement in the development and treatment of dementia and schizophrenia.
Chemical data
- Formula
- C27H38N6O2
- Molecular weight
- 478.6 g/mol
- IUPAC name
- N-[2-[2-[(dipropylamino)methyl]piperidin-1-yl]ethyl]-6-oxo-5H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide
- SMILES
- CCCN(CCC)CC1CCCCN1CCNC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
- InChIKey
- MZDYABXXPZNUCT-UHFFFAOYSA-N
- XLogP
- 2.8
- Polar surface area
- 80.8 Ų
- H-bond donors
- 2
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
42 papers- Muscarinic receptor modulation of acetylcholine release from rat cerebral cortex and hippocampus.Neuroscience letters · 1995
- Crystal structure of 5,11-di-hydro-pyrido[2,3-b][1,4]benzodiazepin-6-one.Acta crystallographica. Section E, Crystallographic communications · 2015
- Repeated nicotine exposure in rats: effects on memory function, cholinergic markers and nerve growth factor.Neuroscience · 2005
- Early changes in M2 muscarinic acetylcholine receptors (mAChRs) induced by sarin intoxication may be linked to long lasting neurological effects.Neurotoxicology · 2018
- Traumatic brain injury causes a decrease in M2 muscarinic cholinergic receptor binding in the rat brain.Brain research · 1994
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 478.305624
Show 3 more facts
- chemical formula
- C₂₇H₃₈N₆O₂
- canonical SMILES
- CCCN(CCC)CC1CCCCN1CCNC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
- subject has role
- parasympatholytic
Sources (1)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
AFDX-384 (BIBN-161) is a drug which acts as a selective antagonist of the muscarinic acetylcholine receptors, with selectivity for the M2 and M4 subtypes. It is used mainly for mapping the distribution of M2 and M4 muscarinic receptors in the brain, and studying their involvement in the development and treatment of dementia and schizophrenia.
==See also== Pirenzepine (M1 selective antagonist)
Excerpted from Wikipedia’s “AFDX384” article, available under the CC BY-SA 4.0 licence.