Structure via PubChem · Public domain (PubChem)
JWH-081
Sign in to saveJWH-081 is an analgesic chemical from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors. With a Ki of 1.2nM it is fairly selective for the CB1 subtype, its affinity at this subtype is measured at approximately 10x the affinity at CB2(12.4nM). It was discovered by and named after John W. Huffman.
Chemical data
- Formula
- C25H25NO2
- Molecular weight
- 371.5 g/mol
- IUPAC name
- (4-methoxynaphthalen-1-yl)-(1-pentylindol-3-yl)methanone
- SMILES
- CCCCCN1C=C(C2=CC=CC=C21)C(=O)C3=CC=C(C4=CC=CC=C43)OC
- InChIKey
- UBMPKJKGUQDHRM-UHFFFAOYSA-N
- XLogP
- 6.3
- Polar surface area
- 31.2 Ų
- H-bond donors
- 0
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 371.189
Show 3 more facts
- chemical formula
- C₂₅H₂₅NO₂
- canonical SMILES
- CCCCCN1C=C(C2=CC=CC=C21)C(=O)C3=CC=C(C4=CC=CC=C43)OC
- Commons category
- JWH-081
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Legal status
- See also
- References
JWH-081 is an analgesic chemical from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors. With a Ki of 1.2nM it is fairly selective for the CB1 subtype, its affinity at this subtype is measured at approximately 10x the affinity at CB2(12.4nM). It was discovered by and named after John W. Huffman.
JWH-081 may be neurotoxic to animals when administered in high doses.
Excerpted from Wikipedia’s “JWH-081” article, available under the CC BY-SA 4.0 licence.