Amorolfine (or amorolfin), is a morpholine antifungal drug that inhibits Δ14-sterol reductase and cholestenol Δ-isomerase, which depletes ergosterol and causes ignosterol to accumulate in the fungal cytoplasmic cell membranes. Sold under the brand name Loceryl among others, amorolfine is commonly available in the form of a nail lacquer, containing 5% amorolfine hydrochloride as the active ingredient. It is used to treat onychomycosis (fungal infection of the toe- and fingernails). Amorolfine 5% nail lacquer in once-weekly or twice-weekly applications was shown in two decades-old studies to be
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{{Infobox drug | image = Amorolfine.svg | image_class = skin-invert-image | alt = | caption = Above: molecular structure of amorolfine Below: 3D representation of an amorolfine molecule | image2 = Amorolfine 3D.png | image_class2 = bg-transparent | alt2 =
| pronounce = | tradename = Loceryl, others | Drugs.com = | MedlinePlus = | DailyMedID = | pregnancy_AU = | pregnancy_AU_comment = | routes_of_administration = | class = | ATC_prefix = D01 | ATC_suffix = AE16 | ATC_supplemental =
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).