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Anisodamine
Sign in to saveAnisodamine, also known as '7β-hydroxyhyoscyamine, is a mAChR anticholinergic and α1 adrenergic receptor antagonist used in the treatment of acute circulatory shock in China. It is given orally or by injection, as a racemic mixture (racanisodamine') or as a hydrobromide salt of the natural enantiometer. Eye drops at 0.5% concentration for slowing the progression of myopia is also available in China.
In the Vinony graph
Vinony's link graph records 866 inbound references to Anisodamine, and connects out to propranolol, atropine and CAS Registry Number.
It is catalogued under topics including Alpha-1 blockers, Chemical pages without DrugBank identifier and Drugboxes which contain changes to watched fields.
Vinony links it to 5 Wikipedia language editions.
Chemical data
- Formula
- C17H23NO4
- Molecular weight
- 305.4 g/mol
- IUPAC name
- [(1S,3S,5S,6S)-6-hydroxy-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] (2S)-3-hydroxy-2-phenylpropanoate
- SMILES
- CN1[C@@H]2C[C@@H](C[C@H]1[C@H](C2)O)OC(=O)[C@H](CO)C3=CC=CC=C3
- InChIKey
- WTQYWNWRJNXDEG-LEOABGAYSA-N
- XLogP
- 0.9
- Polar surface area
- 70 Ų
- H-bond donors
- 2
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Research
466 papers- Anisodamine for the prevention of contrast-induced nephropathy in patients with acute coronary syndrome: a pilot systematic review and meta-analysis of randomized controlled trials.Annals of medicine and surgery (2012) · 2024
- The pharmacological properties of anisodamine.Journal of applied toxicology : JAT · 2007
- Update on the sources, pharmacokinetics, pharmacological action, and clinical application of anisodamine.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2023
- Anisodamine potently inhibits SARS-CoV-2 infection in vitro and targets its main protease.Biochemical and biophysical research communications · 2022
- Ameliorative effect of anisodamine (654-1/654-2) against myocardial dysfunction induced by septic shock via the NF-κB/NLRP-3 or the PI3K-AKT/NF-κB pathway.Phytomedicine : international journal of phytotherapy and phytopharmacology · 2024
via PubMed
Wikidata facts
- Mass
- 305.162708
Show 6 more facts
- subject has role
- parasympatholytic
- chemical formula
- C₁₇H₂₃NO₄
- canonical SMILES
- CN1C2CC(CC1C(C2)O)OC(=O)C(CO)C3=CC=CC=C3
- isomeric SMILES
- CN1[C@@H]2C[C@@H](C[C@H]1[C@H](C2)O)OC(=O)[C@H](CO)C3=CC=CC=C3
- Commons category
- Anisodamine
- found in taxon
- Datura stramonium
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Anisodamine, also known as '7β-hydroxyhyoscyamine, is a mAChR anticholinergic and α1 adrenergic receptor antagonist used in the treatment of acute circulatory shock in China. It is given orally or by injection, as a racemic mixture (racanisodamine') or as a hydrobromide salt of the natural enantiometer. Eye drops at 0.5% concentration for slowing the progression of myopia is also available in China.
Anisodamine is a naturally occurring tropane alkaloid found in some plants of the family Solanaceae including Datura. Its Mandarin Chinese name is given after Anisodus tanguticus ().
Excerpted from Wikipedia’s “Anisodamine” article, available under the CC BY-SA 4.0 licence.