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bamipine
Sign in to saveBamipine (trade name Soventol) is a pharmaceutical drug acting as an H1 antihistamine with anticholinergic properties. It is used as an antipruritic ointment. No oral use is known.
Chemical data
- Formula
- C19H24N2
- Molecular weight
- 280.4 g/mol
- IUPAC name
- N-benzyl-1-methyl-N-phenylpiperidin-4-amine
- SMILES
- CN1CCC(CC1)N(CC2=CC=CC=C2)C3=CC=CC=C3
- InChIKey
- VZSXTYKGYWISGQ-UHFFFAOYSA-N
- XLogP
- 4.1
- Polar surface area
- 6.5 Ų
- H-bond donors
- 0
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- Pruritus, allergic disease
via ChEMBL · EBI
Research
26 papers- Antimycobacterial and H1-antihistaminic activity of 2-substituted piperidine derivatives.Bioorganic & medicinal chemistry · 2008
- [Biotransformation and pharmacokinetics of bamipine in rats. 2. Studies of the pharmacokinetics (1.)].Arzneimittel-Forschung · 1987
- [Biotransformation and pharmacokinetics of bamipine in rats. 2. Pharmacokinetics (P 2)].Arzneimittel-Forschung · 1987
- [Biotransformation and pharmacokinetics of bamipine in rats. 1. biotransformation].Arzneimittel-Forschung · 1987
- Investigation of the mechanism of the electrochemical oxidation of bamipine hydrochloride by voltammetry.The Analyst · 1989
via PubMed
Wikidata facts
- Mass
- 280.194
Show 5 more facts
- chemical formula
- C₁₉H₂₄N₂
- canonical SMILES
- CN1CCC(CC1)N(CC2=CC=CC=C2)C3=CC=CC=C3
- found in taxon
- Piper hispidum
- subject has role
- histamine antagonist
- Commons category
- Bamipine
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
5 sectionsContents
- Adverse effects
- Contraindications and interactions
- Pharmacology
- Pharmacokinetics
- References
Bamipine (trade name Soventol) is a pharmaceutical drug acting as an H1 antihistamine with anticholinergic properties. It is used as an antipruritic ointment. No oral use is known.
==Adverse effects== Side effects are typical of an old (first-generation) antihistamine: tiredness in adults, agitation in children, mydriasis (dilation of the pupils). These effects are rare when bamipine is applied topically as an ointment. Allergic and hypersensitivity reactions are also rare. Acute eczema can be worsened by bamipine ointment.
Excerpted from Wikipedia’s “bamipine” article, available under the CC BY-SA 4.0 licence.