File:Bisoprolol.svg · Wikimedia Commons · See Wikimedia Commons
bisoprolol
Sign in to saveAlso known as (RS)-1-(4-(2-Isopropoxyethoxymethyl)phenoxy)-3-(isopropylamino)-2-propanol, EMD-33512, (+-)-1-((alpha-(2-Isopropoxyethoxy)-p-tolyl)oxy)-3-(isopropylamino)-2-propanol, Congescor, (+-)-1-((alpha-(2-Isopropoxyethoxy)-P-tolyl)oxy)-3-(isopropylamino)-2-propanol, CL-297939, Zebeta®, (RS)-1-(4-(2-isopropoxyethoxymethyl)phenoxy)-3-(isopropylamino)-2-propanol
Bisoprolol, sold under the brand names Bisotab, Concor, Corbis and Zebeta among others, is a beta blocker which is selective for the beta-1 receptor and used for cardiovascular diseases, including tachyarrhythmias, high blood pressure, angina, and heart failure. It is taken by mouth.
OverviewAI-generated
Bisoprolol is a chemical compound with the formula C₁₈H₃₁NO₄. Its IUPAC name is 1-(propan-2-ylamino)-3-[4-(2-propan-2-yloxyethoxymethyl)phenoxy]propan-2-ol. The substance has a molecular weight of 325.4 and a mass of 325.225308. It possesses a charge of 0, with two hydrogen bond donors and five hydrogen bond acceptors. The calculated xlogp value is 1.9, and the topological polar surface area is 60.
The defined daily dose for bisoprolol is 10. The compound is the subject of 2325 entries in the PubMed literature database. Additionally, it is referenced by 618 other encyclopedia articles.
Synthesized by Vinony from 18 facts across 4 sources: Wikidata, PubMed, PubChem, Vinony graph. Generated from structured data (not the Wikipedia text) and checked against those facts — may still contain errors.
Key facts
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 459980153
- Drug.image
- Bisoprolol.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 240
- Drug.image2
- Bisoprolol ball-and-stick.png
- Drug.image_class2
- bg-transparent
- Drug.chirality
- Racemic mixture
- Drug.tradename
- Zebeta, Monocor, others
- Drug.MedlinePlus
- a693024
- Drug.pregnancy_AU
- C
- Drug.routes_of_administration
- By mouth
- Drug.ATC_prefix
- C07
- Drug.ATC_suffix
- AB07
- Drug.legal_CA
- Rx-only
- Drug.legal_US
- Rx-only
- Drug.legal_status
- Rx-only
- Drug.bioavailability
- >90%
via Wikipedia infobox
Chemical data
- Formula
- C18H31NO4
- Molecular weight
- 325.4 g/mol
- IUPAC name
- 1-(propan-2-ylamino)-3-[4-(2-propan-2-yloxyethoxymethyl)phenoxy]propan-2-ol
- SMILES
- CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O
- InChIKey
- VHYCDWMUTMEGQY-UHFFFAOYSA-N
- XLogP
- 1.9
- Polar surface area
- 60 Ų
- H-bond donors
- 2
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Research
2,325 papers- Beta-blockers for the treatment of arrhythmias: Bisoprolol - a systematic review.Annales pharmaceutiques francaises · 2022
- Pharmacogenetic polymorphisms affecting bisoprolol response.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2021
- Bisoprolol: A comprehensive profile.Profiles of drug substances, excipients, and related methodology · 2021
- Bisoprolol: is this just another beta-blocker for hypertension or angina?The Annals of pharmacotherapy · 1995
- Bisoprolol: a review of its use in chronic heart failure.Drugs · 2002
via PubMed
~8 min read
Encyclopedic overview
10 sectionsContents
- Medical uses
- Side effects
- Cautions
- Pharmacology
- Mechanism of action
- β<sub>1</sub>-selectivity
- Renin-angiotensin system
- Pharmacokinetics
- Chemistry
- References
{{Infobox drug | Watchedfields = changed | verifiedrevid = 459980153 | image = Bisoprolol.svg | image_class = skin-invert-image | width = 240 | alt = | image2 = Bisoprolol ball-and-stick.png | image_class2 = bg-transparent | alt2 = | chirality = Racemic mixture
| tradename = Zebeta, Monocor, others | Drugs.com = | MedlinePlus = a693024 | pregnancy_AU = C | pregnancy_category = | routes_of_administration = By mouth | ATC_prefix = C07 | ATC_suffix = AB07
Excerpted from Wikipedia’s “bisoprolol” article, available under the CC BY-SA 4.0 licence.