Structure via PubChem · Public domain (PubChem)
bromhexine
Sign in to saveAlso known as N-Cyclohexyl-N-methyl-(2-amino-3,5-dibrombenzyl)amine, Tauglicolo, Fluibron, Bromexina, Bromhexina, Bromhexinum, 3,5-Dibromo-N(alpha)-cyclohexyl-N(alpha)-methyltoluene-alpha-2-diamine
Bromhexine, sold under the brand name Bisolvon among others, is a mucolytic drug used in the treatment of respiratory disorders associated with viscid or excessive mucus. It was developed in the research laboratory of Boehringer Ingelheim in the late 1950s as an active ingredient for pharmaceutical use, patented in 1961, introduced in 1963 under the trademark of Bisolvon® and came into medical use in 1966.
Chemical data
- Formula
- C14H20Br2N2
- Molecular weight
- 376.13 g/mol
- IUPAC name
- 2,4-dibromo-6-[[cyclohexyl(methyl)amino]methyl]aniline
- SMILES
- CN(CC1=C(C(=CC(=C1)Br)Br)N)C2CCCCC2
- InChIKey
- OJGDCBLYJGHCIH-UHFFFAOYSA-N
- XLogP
- 4.3
- Polar surface area
- 29.3 Ų
- H-bond donors
- 1
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Research
1,366 papers- Bromhexine.Indian pediatrics · 1990
- Beyond the lungs: Exploring diverse applications of bromhexine and ambroxol.Life sciences · 2024
- Enhancement of lung levels of antibiotics by ambroxol and bromhexine.Expert opinion on drug metabolism & toxicology · 2019
- [Bromhexine].Deutsche medizinische Wochenschrift (1946) · 1979
- [Bromhexine (Bisolvon). An evaluation from the literature].Ugeskrift for laeger · 1974
via PubMed
~3 min read
Encyclopedic overview
3 sectionsContents
- Function
- Brand names
- References
{{Drugbox | Verifiedfields = changed | verifiedrevid = 443272001 | IUPAC_name = 2,4-Dibromo-6-{[cyclohexyl(methyl)amino]methyl}aniline | image = Bromhexine-PlainSVG.svg | image_class = skin-invert-image | image2 = Bromhexine-from-xtal-3D-bs-17.png | image_class2 = bg-transparent
| tradename = Bisolvon, others | Drugs.com = | pregnancy_AU = A | pregnancy_AU_comment = | pregnancy_category = | routes_of_administration = | ATC_prefix = R05 | ATC_suffix = CB02
Excerpted from Wikipedia’s “bromhexine” article, available under the CC BY-SA 4.0 licence.