ブロムヘキシン

Also known as N-Cyclohexyl-N-methyl-(2-amino-3,5-dibrombenzyl)amine, Tauglicolo, Fluibron, Bromexina, Bromhexina, Bromhexinum, 3,5-Dibromo-N(alpha)-cyclohexyl-N(alpha)-methyltoluene-alpha-2-diamine, Bromhexine

Bromhexine, sold under the brand name Bisolvon among others, is a mucolytic drug used in the treatment of respiratory disorders associated with viscid or excessive mucus. It was developed in the research laboratory of Boehringer Ingelheim in the late 1950s as an active ingredient for pharmaceutical use, patented in 1961, introduced in 1963 under the trademark of Bisolvon® and came into medical use in 1966.

In the Vinony graph

Within Vinony's link graph, ブロムヘキシン is referenced by 98 other articles, and connects out to antitussive, mucokinetic and liver.

It is catalogued under topics including Anilines, Antidotes and Bromobenzene derivatives.

Its subject is documented across 26 Wikipedia language editions.

Chemical data

Formula: C14H20Br2N2
Molecular weight: 376.13 g/mol
IUPAC name: 2,4-dibromo-6-[[cyclohexyl(methyl)amino]methyl]aniline
SMILES: CN(CC1=C(C(=CC(=C1)Br)Br)N)C2CCCCC2
InChIKey: OJGDCBLYJGHCIH-UHFFFAOYSA-N
XLogP: 4.3
Polar surface area: 29.3 Å²
H-bond donors: 1
H-bond acceptors: 2
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Small molecule
Indications: malaria, COVID-19

via ChEMBL · EBI

Research

1,366 papers

Bromhexine.Indian pediatrics · 1990
Beyond the lungs: Exploring diverse applications of bromhexine and ambroxol.Life sciences · 2024
Enhancement of lung levels of antibiotics by ambroxol and bromhexine.Expert opinion on drug metabolism & toxicology · 2019
[Bromhexine].Deutsche medizinische Wochenschrift (1946) · 1979
[Bromhexine (Bisolvon). An evaluation from the literature].Ugeskrift for laeger · 1974

via PubMed

Wikidata facts

Subclass of: chemical compound
Has part: bromine
Mass: 373.99932284000005
Has use: medication

Show 8 more facts

canonical SMILES: CN(CC1=CC(=CC(=C1N)Br)Br)C2CCCCC2
chemical formula: C₁₄H₂₀Br₂N₂
subject has role: mucokinetic
World Health Organisation international non-proprietary name: bromhexine
medical condition treated: cough
Commons category: Bromhexine
found in taxon: Justicia adhatoda
defined daily dose: 24

Sources (3)

via Wikidata · CC0

Article · 日本語

ブロムヘキシン（英: Bromhexine）は去痰薬の一つであり、分子式C14H20N2Br2で表される有機臭素化合物。商品名はビソルボンなど。医薬品としては塩酸塩 - Hydrochloride（ブロムヘキシン塩酸塩 - 英: Bromhexine hydrochloride）の形で用いられる。ブロムヘキシン塩酸塩は水溶液中でイオン化され、アルカリ性の化合物と反応することで、難溶性のブロムヘキシンとなり沈殿が生じる。

Abstract from DBpedia / Wikipedia · CC BY-SA