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Also known as APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56, caspase 9

Caspase-9 is an enzyme that in humans is encoded by the CASP9 gene. It is an initiator caspase, critical to the apoptotic pathway found in many tissues. Caspase-9 homologs have been identified in all mammals for which they are known to exist, such as Mus musculus and Pan troglodytes.

Gene data

CASP9

Name: caspase 9
Type: protein-coding
Position: 15,489,724–15,526,534 (−)
Aliases: APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56
Ensembl: ENSG00000132906
RefSeq RNA: NM_001229.5, NM_001278054.2, NM_032996.3, NR_102732.2, NR_102733.2
RefSeq protein: NP_001220.2, NP_001264983.1, NP_127463.2, XP_005246071.1, XP_011540575.1

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013].

Pathways

p53 signaling pathway - Homo sapiens (human)PI3K-Akt signaling pathway - Homo sapiens (human)Apoptosis - Homo sapiens (human)Apoptosis - multiple species - Homo sapiens (human)VEGF signaling pathway - Homo sapiens (human)Thyroid hormone signaling pathway - Homo sapiens (human)Alzheimer disease - Homo sapiens (human)Parkinson disease - Homo sapiens (human)Amyotrophic lateral sclerosis - Homo sapiens (human)Huntington disease - Homo sapiens (human)

via MyGene.info

Gene · Ensembl

caspase 9

Symbol: CASP9
Biotype: Protein coding
Organism: Homo sapiens
Location: 1:15,489,724-15,526,534
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein CASP9 PDB 1jxq.png

Show 8 more facts

HomoloGene ID: 31024
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/842
genomic end: 15853029
genomic start: 15817327
chromosome: human chromosome 1
cytogenetic location: 1p36.21
Commons category: Caspase 9

Sources (6)

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