chlorothiazide

Also known as 6-chloro-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxide, 6-chloro-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[1,2,4]thiadiazine-7-sulfonic acid amide

Chlorothiazide, sold under the brand name Diuril among others, is an organic compound used as a diuretic and as an antihypertensive.

Chemical data

Formula: C7H6ClN3O4S2
Molecular weight: 295.7 g/mol
IUPAC name: 6-chloro-1,1-dioxo-4H-1lambda6,2,4-benzothiadiazine-7-sulfonamide
SMILES: C1=C2C(=CC(=C1Cl)S(=O)(=O)N)S(=O)(=O)N=CN2
InChIKey: JBMKAUGHUNFTOL-UHFFFAOYSA-N
XLogP: -0.2
Polar surface area: 135 Å²
H-bond donors: 2
H-bond acceptors: 6
Formal charge: 0

via PubChem

Research

9,337 papers

Chlorothiazide.British journal of clinical pharmacology · 1982
Chlorothiazide.Neonatal network : NN · 1993
CHLOROTHIAZIDE.Journal of the Indian Medical Association · 1959
[Chlorothiazide].Anales de farmacia hospitalaria · 1960
[Chlorothiazide diuretics].Lekarska veda v zahranici · 1960

via PubMed

Wikidata facts

Mass: 294.948825

Show 5 more facts

Commons category: Chlorothiazide
chemical formula: C₇H₆ClN₃O₄S₂
canonical SMILES: C1=C2C(=CC(=C1Cl)S(=O)(=O)N)S(=O)(=O)N=CN2
World Health Organisation international non-proprietary name: chlorothiazide
defined daily dose: 0.5

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Article

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Contents

Indications
Contraindications
Side effects
History
See also
References

Chlorothiazide, sold under the brand name Diuril among others, is an organic compound used as a diuretic and as an antihypertensive.

It is used both within the hospital setting or for personal use to manage excess fluid associated with congestive heart failure. Most often taken in pill form, it is usually taken orally once or twice a day. In the ICU setting, chlorothiazide is given to diurese a patient in addition to furosemide (Lasix). Working in a separate mechanism from furosemide and absorbed enterically as a reconstituted suspension administered through a nasogastric tube (NG tube), the two drugs potentiate one another.