bromodiphenhydramine
Bromazine, sold under the brand names Ambodryl, Ambrodil, and Deserol among others, also known as bromodiphenhydramine, is an antihistamine and anticholinergic medication of the ethanolamine class. It is an analogue of diphenhydramine with a bromine substitution on one of the phenyl rings.
Chemical data
- Formula
- C17H20BrNO
- Molecular weight
- 334.2 g/mol
- IUPAC name
- 2-[(4-bromophenyl)-phenylmethoxy]-N,N-dimethylethanamine
via PubChem
Wikidata facts
- Subclass of
- organobromine compound
- Mass
- +333.072826
- Has use
- medication
Show 2 more facts
- P2175
- insomnia
- P2868
- anticholinergic
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Article
3 sectionsContents
- Synthesis
- Side effects
- References
Bromazine, sold under the brand names Ambodryl, Ambrodil, and Deserol among others, also known as bromodiphenhydramine, is an antihistamine and anticholinergic medication of the ethanolamine class. It is an analogue of diphenhydramine with a bromine substitution on one of the phenyl rings.
==Synthesis== class=skin-invert-image|thumb|center|500px|Synthesis: Patent: Grignard reaction between phenylmagnesium bromide and para-bromobenzaldehyde [1122-91-4] (1) gives p-bromobenzhydrol [29334-16-5] (2). Halogenation with acetyl bromide in benzene solvent gives p-bromo-benzhydrylbromide [18066-89-2] (3). Finally, etherification with deanol completed the synthesis of Bromazine (4).