CKMT2

Also known as SMTCK, creatine kinase, mitochondrial 2

gene umano

In the Vinony graph

Vinony's link graph records 3 inbound references to CKMT2, and connects out to PubMed, human chromosome 5 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 5.

Vinony links it to 5 Wikipedia language editions.

Gene data

CKMT2

Name: creatine kinase, mitochondrial 2
Type: protein-coding
Position: 81,232,673–81,266,400 (+)
Aliases: SMTCK
Ensembl: ENSG00000131730
RefSeq RNA: NM_001099735.2, NM_001099736.2, NM_001825.3
RefSeq protein: NP_001093205.1, NP_001093206.1, NP_001816.2

Mitochondrial creatine kinase (MtCK) is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Sarcomeric mitochondrial creatine kinase has 80% homology with the coding exons of ubiquitous mitochondrial creatine kinase. This gene contains sequences homologous to several motifs that are shared among some nuclear genes encoding mitochondrial proteins and thus may be essential for the coordinated activation of these genes during mitochondrial biogenesis. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].