كورتيزول

Also known as 4-pregnen-11beta,17alpha,21-triol-3,20-dione, (11beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione, 11beta,17alpha,21-trihydroxy-4-pregnene-3,20-dione, 11beta-hydrocortisone, HC, (1S,2R,10S,11S,14S,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one, hydrocortisone, Kendall's compound F

الكورتيزول هو الهرمون الرئيسي المرتبط بالتوتر والاستجابة للكر والفر، ويعد هذا رداً اعتياديا عند شعور الأنسان بالتهديد او الخطر وتؤدي زيادة الكورتيزول الى قوة جديدة وطاقة جديدة، في استجابة الكر والفر يقمع الكورتيزول اي وظائف لا لزوم لها

OverviewAI-generated

Cortisol is a chemical compound with the formula C₂₁H₃₀O₅. It has a melting point of 214 and a mass of 362.209. The substance is also identified by the stylized name Solu-CORTEF and carries an MCN code of 2937.21.20. Its defined daily dose is 30.

Chemical properties include a weight of 362.5, an xlogp of 1.6, and a tpsa of 94.8. The molecule features three hydrogen bond donors and five hydrogen bond acceptors, with a charge of 0. It is associated with a PubMed query count of 119672 and is referenced by 1,410 other encyclopedia articles.

Synthesized by Vinony from 21 facts across 4 sources: Wikidata, PubChem, PubMed, Vinony graph. Generated from structured data (not the Wikipedia text) and checked against those facts — may still contain errors.

Chemical data

Formula: C21H30O5
Molecular weight: 362.5 g/mol
IUPAC name: (8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
SMILES: C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C)O
InChIKey: JYGXADMDTFJGBT-VWUMJDOOSA-N
XLogP: 1.6
Polar surface area: 94.8 Å²
H-bond donors: 3
H-bond acceptors: 5
Formal charge: 0

via PubChem

Research

119,672 papers

Cortisol: Biosensing and detection strategies.ReviewClinica chimica acta; international journal of clinical chemistry · 2024Balasamy S, Atchudan R, Arya S et al.DOI: 10.1016/j.cca.2024.119888
Salivary cortisol and cortisone in the clinical setting.ReviewCurrent opinion in endocrinology, diabetes, and obesity · 2017Blair J, Adaway J, Keevil B et al.DOI: 10.1097/MED.0000000000000328
Cortisol Detection Methods and the Hormone's Role in Evaluating Circadian Rhythm Disruption.ReviewInternational journal of molecular sciences · 2025Juliana N, Maluin SM, Effendy NM et al.DOI: 10.3390/ijms26189141
Advancements in Cortisol Detection: From Conventional Methods to Next-Generation Technologies for Enhanced Hormone Monitoring.ReviewACS sensors · 2024Vignesh V, Castro-Dominguez B, James TD et al.DOI: 10.1021/acssensors.3c01912
Obesity and cortisol status.ReviewHormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2005Salehi M, Ferenczi A, Zumoff BDOI: 10.1055/s-2005-861374
Early life stress and cortisol: A meta-analysis.ReviewHormones and behavior · 2018Fogelman N, Canli TDOI: 10.1016/j.yhbeh.2017.12.014
Measuring cortisol in human psychobiological studies.ReviewPhysiology & behavior · 2007Levine A, Zagoory-Sharon O, Feldman R et al.DOI: 10.1016/j.physbeh.2006.08.025
Cortisol metabolism, cortisol sensitivity and the pathogenesis of leprosy reactions.ReviewTropical medicine & international health : TM & IH · 1999Rook GA, Baker RDOI: 10.1046/j.1365-3156.1999.00432.x

via PubMed

Article · العربية

الكورتيزول (بالإنجليزية: Cortisol)‏ هو هرمون ستيرويدي يفرز من قشرة الغدة الكظرية متصولة بالكلى. يفرز استجابةً للإجهاد أو لانخفاض مستوى هرمونات القشريات السكرية في الدم. الكثير من المركبات المصنوعة من الكورتيزول تستخدم لعلاج العديد من الأمراض المختلفة.

Abstract from DBpedia / Wikipedia · CC BY-SA