cortisolo

Also known as 4-pregnen-11beta,17alpha,21-triol-3,20-dione, (11beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione, 11beta,17alpha,21-trihydroxy-4-pregnene-3,20-dione, 11beta-hydrocortisone, HC, (1S,2R,10S,11S,14S,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one, hydrocortisone, Kendall's compound F

composto chimico

AI overview

Cortisol is a hormone your body naturally produces that helps regulate stress responses and other important functions. When doctors use it as a medicine, they call it hydrocortisone, and it can help treat various conditions related to inflammation and hormone imbalances.

AI-generated from the Wikipedia summary — may contain errors.

Chemical data

Formula: C21H30O5
Molecular weight: 362.5 g/mol
IUPAC name: (8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
SMILES: C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C)O
InChIKey: JYGXADMDTFJGBT-VWUMJDOOSA-N
XLogP: 1.6
Polar surface area: 94.8 Å²
H-bond donors: 3
H-bond acceptors: 5
Formal charge: 0

via PubChem

Research

119,672 papers

Cortisol: Biosensing and detection strategies.ReviewClinica chimica acta; international journal of clinical chemistry · 2024Balasamy S, Atchudan R, Arya S et al.DOI: 10.1016/j.cca.2024.119888
Salivary cortisol and cortisone in the clinical setting.ReviewCurrent opinion in endocrinology, diabetes, and obesity · 2017Blair J, Adaway J, Keevil B et al.DOI: 10.1097/MED.0000000000000328
Cortisol Detection Methods and the Hormone's Role in Evaluating Circadian Rhythm Disruption.ReviewInternational journal of molecular sciences · 2025Juliana N, Maluin SM, Effendy NM et al.DOI: 10.3390/ijms26189141
Advancements in Cortisol Detection: From Conventional Methods to Next-Generation Technologies for Enhanced Hormone Monitoring.ReviewACS sensors · 2024Vignesh V, Castro-Dominguez B, James TD et al.DOI: 10.1021/acssensors.3c01912
Obesity and cortisol status.ReviewHormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2005Salehi M, Ferenczi A, Zumoff BDOI: 10.1055/s-2005-861374
Early life stress and cortisol: A meta-analysis.ReviewHormones and behavior · 2018Fogelman N, Canli TDOI: 10.1016/j.yhbeh.2017.12.014
Measuring cortisol in human psychobiological studies.ReviewPhysiology & behavior · 2007Levine A, Zagoory-Sharon O, Feldman R et al.DOI: 10.1016/j.physbeh.2006.08.025
Cortisol metabolism, cortisol sensitivity and the pathogenesis of leprosy reactions.ReviewTropical medicine & international health : TM & IH · 1999Rook GA, Baker RDOI: 10.1046/j.1365-3156.1999.00432.x

via PubMed

Wikidata facts

Mass: 362.209

Show 9 more facts

chemical formula: C₂₁H₃₀O₅
melting point: 212.5
Commons category: Cortisol
canonical SMILES: CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4(C(=O)CO)O)C)O
isomeric SMILES: C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C)O
World Health Organisation international non-proprietary name: hydrocortisone
MCN code: 2937.21.20
stylized name: Solu-CORTEF
defined daily dose: 30

Sources (10)

via Wikidata · CC0

Article · Italiano

Il cortisolo (o idrocortisone) è un ormone prodotto dalle ghiandole surrenali, più precisamente dalla zona fascicolata della loro porzione corticale. È un ormone di tipo steroideo, derivante cioè dal colesterolo, e in particolare appartiene alla categoria dei glucocorticoidi, di cui fa parte anche il corticosterone (meno attivo).

Abstract from DBpedia / Wikipedia · CC BY-SA