کریسپر

Also known as clustered regularly interspaced short palindromic repeats

thumb|262px|Diagram of the CRISPR prokaryotic antiviral defense mechanism CRISPR (; acronym for clustered regularly interspaced short palindromic repeats) is a family of DNA sequences found in the genomes of prokaryotic organisms such as bacteria and archaea. Each sequence within an individual prokaryotic CRISPR is derived from a DNA fragment of a bacteriophage that had previously infected the prokaryote or one of its ancestors. These sequences are used to detect and destroy DNA from similar bacteriophages during subsequent infections. Hence these sequences play a key role in the antiviral (i.

Key facts

Nonhuman protein.Name: Cascade (CRISPR-associated complex for antiviral defense)
Nonhuman protein.image: 4QYZ.png
Nonhuman protein.caption: CRISPR Cascade protein (cyan) bound to CRISPR RNA (green) and phage DNA (red)
Nonhuman protein.Organism: Escherichia coli
Nonhuman protein.TaxID: 511145
Nonhuman protein.Symbol: CRISPR
Nonhuman protein.EntrezGene: 947229
Nonhuman protein.PDB: 4QYZ
Nonhuman protein.UniProt: P38036
Nonhuman protein.RefSeqProtein: NP_417241.1
Protein family.Symbol: CRISPR_assoc
Protein family.Name: CRISPR associated protein CasC/Cse3/Cas6 (Type I effector RNase)
Protein family.image: PDB 1wj9 EBI.jpg
Protein family.caption: Crystal structure of a crispr-associated protein from Thermus thermophilus
Protein family.Pfam: PF08798
Protein family.InterPro: IPR010179
Protein family.CDD: cd09727
Protein family.Pfam_clan: CL0362