DBX1
Sign in to saveAlso known as developing brain homeobox 1, HLX1
Homeobox protein DBX1, also known as developing brain homeobox protein 1, is a protein that in humans is encoded by the DBX1 gene. The DBX1 gene is a transcription factor gene that is pivotal in interneuron differentiation in the ventral spinal cord.
Gene data
DBX1- Name
- developing brain homeobox 1
- Type
- protein-coding
- Aliases
- HLX1
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in cell differentiation in spinal cord and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within ventral spinal cord interneuron specification. Predicted to be located in nucleus. Predicted to be part of chromatin. [provided by Alliance of Genome Resources, Apr 2022]
via MyGene.info
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 19002
- exact match
- identifiers.org/ncbigene/120237
- genomic end
- 20160475
- genomic start
- 20177701
- cytogenetic location
- 11p15.1
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Homeobox protein DBX1, also known as developing brain homeobox protein 1, is a protein that in humans is encoded by the DBX1 gene. The DBX1 gene is a transcription factor gene that is pivotal in interneuron differentiation in the ventral spinal cord.
The spinal interneurons V0 and V1 are derived from progenitor domains that are differentiated by the expression of homeodomain proteins DBX1 and DBX2. DBX1 is spatially restricted and has a critical role in establishing the distinction of V0 and V1 neuronal fate. In DBX1 mutant mice, neural progenitors fail to generate V0 interneurons and instead gave rise to interneurons expressing V1 characteristics, such as their transcription factor profile, neurotransmitter phenotype, migratory pattern, and aspects of their axonal trajectory, suggesting that this single homeodomain transcription factor coordinates many of the differentiated properties of one class of interneurons generated in the ventral spinal cord.