TNFRSF10B

Name

TNF receptor superfamily member 10b

Type

protein-coding

Position

23,020,133–23,069,121 (−)

Aliases

CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB

Ensembl

ENSG00000120889

RefSeq RNA

NM_003842.5, NM_147187.3, NR_027140.2

RefSeq protein

NP_003833.4, NP_671716.2

The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009].

via MyGene.info

Gene · Ensembl

TNF receptor superfamily member 10b

Symbol

TNFRSF10B

Biotype

Protein coding

Organism

Homo sapiens

Location

8:23,020,133-23,069,121

Strand

Reverse (−)

Assembly

GRCh38