FADD
Sign in to saveAlso known as GIG3, MORT1, Fas associated via death domain, IMD90
Gen der Spezies Homo sapiens
Gene data
FADD- Name
- Fas associated via death domain
- Type
- protein-coding
- Position
- 70,203,262–70,220,615 (+)
- Aliases
- GIG3, IMD90, MORT1
- Ensembl
- ENSG00000168040
- RefSeq RNA
- NM_003824.4
- RefSeq protein
- NP_003815.1
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
Fas associated via death domain
- Symbol
- FADD
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:70,203,262-70,220,615
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- FADD based on pdb file 2GF5.gif
Show 8 more facts
- HomoloGene ID
- 2836
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/8772
- genomic end
- 70053496
- genomic start
- 70203296
- chromosome
- human chromosome 11
- cytogenetic location
- 11q13.3
- Commons category
- FAS-associated death domain protein
via Wikidata · CC0