Forkhead box P3
Sign in to saveAlso known as forkhead box protein P3, FOXP3delta7, FOXP3, immunodeficiency, polyendocrinopathy, enteropathy, X-linked, immune dysregulation, polyendocrinopathy, enteropathy, X-linked, scurfin
FOXP3 (forkhead box P3), also known as scurfin, is a protein involved in immune system responses. A member of the FOX protein family, FOXP3 appears to function as a master regulator of the regulatory pathway in the development and function of regulatory T cells. Regulatory T cells generally turn the immune response down. In cancer, an excess of regulatory T cell activity can prevent the immune system from destroying cancer cells. In autoimmune disease, a deficiency of regulatory T cell activity can allow other autoimmune cells to attack the body's own tissues.
In the Vinony graph
Vinony's link graph records 956 inbound references to Forkhead box P3, and connects out to transforming growth factor-beta, PubMed and X chromosome.
Vinony files it under Forkhead transcription factors and Genes on human chromosome X.
Vinony links it to 14 Wikipedia language editions.
Protein · UniProt
Forkhead box protein P3
- Gene
- FOXP3
- Organism
- Homo sapiens (Human)
- Length
- 431 aa
- Molecular mass
- 47,244 Da
- Evidence
- 1: Evidence at protein level
Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg) (PubMed:17377532, PubMed:21458306, PubMed:23947341, PubMed:24354325, PubMed:24722479, PubMed:24835996, PubMed:30513302, PubMed:32644293). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells (PubMed:23169781). Can act either as a transcriptional repressor or a transcriptional activator depen…
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
19 registered- COMPLETEDEpigenetic Features of FoxP3 in Children With Cow's Milk AllergyFederico II University · NCT02779881
- NACOMPLETEDDistinct Response of CD4+CD25+Foxp3+ and IL-10-secreting Type I T Regulatory Cells to Cluster Specific Immunotherapy in Allergic Rhinitis ChildrenBeijing Tongren Hospital · NCT01291381
- COMPLETEDAnalysis of Foxp3 and Vimentin Expression in Renal Transplant RecipientAssistance Publique - Hôpitaux de Paris · NCT01443013
- PHASE2/PHASE3COMPLETEDThe Effect of Oral Nanocurcumin as an Adjuvant Therapy for Anogenital Warts: Evaluation of Clinical Improvement, NFĸB, IFN-γ, and FOXP3+TReg From Lesions TissueIndonesia University · NCT06281353
- PHASE2WITHDRAWNPembrolizumab/Lenvatinib With and Without Healthy Donor FMT (hdFMT) in Relapsed/ Refractory (R/R) MelanomaDiwakar Davar · NCT06030037
- NAUNKNOWNTopical Ethanol Extract (Piper Crocatum) for Anogenital WartsHasanuddin University · NCT05622916
Wikidata facts
- Instance of
- protein
- Image
- FOXP3.png
Show 3 more facts
- found in taxon
- Homo sapiens
- cell component
- cytoplasm
- exact match
- purl.uniprot.org/uniprot/Q9BZS1
via Wikidata · CC0
~11 min read
Encyclopedic overview
10 sectionsContents
- Structure
- Identification
- Physiology
- Pathophysiology
- Role in cancer
- Autoimmune
- See also
- References
- Further reading
- External links
FOXP3 (forkhead box P3), also known as scurfin, is a protein involved in immune system responses. A member of the FOX protein family, FOXP3 appears to function as a master regulator of the regulatory pathway in the development and function of regulatory T cells. Regulatory T cells generally turn the immune response down. In cancer, an excess of regulatory T cell activity can prevent the immune system from destroying cancer cells. In autoimmune disease, a deficiency of regulatory T cell activity can allow other autoimmune cells to attack the body's own tissues.
While the precise control mechanism has not yet been established, FOX proteins belong to the forkhead/winged-helix family of transcriptional regulators and are presumed to exert control via similar DNA binding interactions during transcription. In regulatory T cell model systems, the FOXP3 transcription factor occupies the promoters for genes involved in regulatory T-cell function, and may inhibit transcription of key genes following stimulation of T cell receptors.
Excerpted from Wikipedia’s “Forkhead box P3” article, available under the CC BY-SA 4.0 licence.