Forkhead box A2
Sign in to saveAlso known as TCF-3B, hepatic nuclear factor-3-beta, forkhead box protein A2, hepatocyte nuclear factor 3-beta, transcription factor 3B, HNF-3-beta, HNF-3B, FOXA2
Forkhead box protein A2 (FOXA2), also known as hepatocyte nuclear factor 3-beta (HNF-3B), is a transcription factor that plays an important role during development, in mature tissues and, when dysregulated or mutated, also in cancer.
Protein · UniProt
Hepatocyte nuclear factor 3-beta
- Gene
- FOXA2
- Organism
- Homo sapiens (Human)
- Length
- 457 aa
- Molecular mass
- 48,306 Da
- Evidence
- 1: Evidence at protein level
Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple end…
Swiss-Prot (reviewed) · via UniProt
Research
321 papers- Forkhead box protein A2 and T helper type 2-mediated pulmonary inflammation.World journal of methodology · 2015
- Genetic Pathogenesis and Treatment of Forkhead Box A2 Hyperinsulinemia.Endocrine, metabolic & immune disorders drug targets · 2025
- Apolipoprotein M.Clinica chimica acta; international journal of clinical chemistry · 2015
- Forkhead box A2 Promotes Colorectal Cancer Progression and Targets BCL2-Associated X (BAX) Protein.Iranian journal of public health · 2023
- Forkhead box protein A2 alleviates toll-like receptor 4-mediated inflammation, endoplasmic reticulum stress, autophagy, and apoptosis induced by lipopolysaccharide in bovine hepatocytes.Journal of dairy science · 2023
via PubMed
~3 min read
Article
4 sectionsContents
- Structure
- Functions
- References
- External links
Forkhead box protein A2 (FOXA2), also known as hepatocyte nuclear factor 3-beta (HNF-3B), is a transcription factor that plays an important role during development, in mature tissues and, when dysregulated or mutated, also in cancer.
== Structure == FOXA2 belongs to a subfamily of the Forkhead box (FOX) transcription factors, the other members being FOXA1 and FOXA3. This subfamily of mammalian FOX proteins was first identified because of their ability to bind DNA in rat liver nuclear extracts. The proteins were therefore originally named hepatocyte nuclear factor 3 alpha, beta and gamma. These transcription factors contain a forkhead domain (also known as the winged-helix domain) flanked by sequences necessary for nuclear localization. Their N- and C-termini are also conserved and serve as transactivation domains.