Structure via PubChem · Public domain (PubChem)
Halcinonide
Sign in to saveAlso known as (4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS)-6b-(chloroacetyl)-4b-fluoro-5-hydroxy-4a,6a,8,8-tetramethyl-3,4,4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-tetradecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one, Halcinonid, Halcinonida, Halcinonidum
Halcinonide is a high potency corticosteroid, in group II (second most potent group) under US classification. It is used topically (in a 0.05% cream provided as Halog) in the treatment of certain skin conditions. It is available as a generic medication.
Chemical data
- Formula
- C24H32ClFO5
- Molecular weight
- 455 g/mol
- IUPAC name
- (1S,2S,4R,8S,9S,11S,12R,13S)-8-(2-chloroacetyl)-12-fluoro-11-hydroxy-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icos-17-en-16-one
- SMILES
- C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@]2([C@H](C[C@]4([C@H]3C[C@@H]5[C@]4(OC(O5)(C)C)C(=O)CCl)C)O)F
- InChIKey
- MUQNGPZZQDCDFT-JNQJZLCISA-N
- XLogP
- 3.6
- Polar surface area
- 72.8 Ų
- H-bond donors
- 1
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1974
- Admin. routes
- topical
- Indications
- skin disease
via ChEMBL · EBI
Research
101 papers- Halcinonide activates smoothened to ameliorate ischemic stroke injury.Life sciences · 2025
- Tildrakizumab in Combination With Topical Halcinonide 0.1% Ointment for Treating Moderate to Severe Plaque Psoriasis.Journal of drugs in dermatology : JDD · 2023
- Demonstration of the biphasic release of 0.1% halcinonide cream.Journal of drugs in dermatology : JDD · 2015
- Topical halcinonide and betamethasone valerate effects on plasma cortisol: acute and subacute usage studies.Archives of dermatology · 1977
- Therapeutic uses of halcinonide.Scottish medical journal · 1977
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 454.192
- Has use
- medication
Show 4 more facts
- isomeric SMILES
- C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@]2([C@H](C[C@]4([C@H]3C[C@@H]5[C@]4(OC(O5)(C)C)C(=O)CCl)C)O)F
- canonical SMILES
- CC1(OC2CC3C4CCC5=CC(=O)CCC5(C4(C(CC3(C2(O1)C(=O)CCl)C)O)F)C)C
- chemical formula
- C₂₄H₃₂ClFO₅
- subject has role
- anti-inflammatory agent
Sources (2)
via Wikidata · CC0
Available in 8 languages
via Wikidata sitelinks · CC0