Hepatocyte growth factor

Protein · UniProt

Hepatocyte growth factor

Gene

HGF

Organism

Homo sapiens (Human)

Length

728 aa

Molecular mass

83,134 Da

Evidence

1: Evidence at protein level

Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types (PubMed:20624990). Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (PubMed:15167892, PubMed:20977675). Activates MAPK signaling following TMPRSS13 cleavage and activation (PubMed:20977675)

• Hepatocyte Growth Factor and Macrophage-stimulating Protein "Hinge" Analogs to Treat Pancreatic Cancer.Current cancer drug targets · 2019
• Hepatocyte growth factor/MET and CD44 in colorectal cancer: partners in tumorigenesis and therapy resistance.Biochimica et biophysica acta. Reviews on cancer · 2020
• Hepatocyte growth factor in physiology and infectious diseases.Cytokine · 2017
• Hepatocyte growth factor/MET in cancer progression and biomarker discovery.Cancer science · 2017
• Hepatocyte growth factor promotes melanoma metastasis through ubiquitin-specific peptidase 22-mediated integrins upregulation.Cancer letters · 2024

via PubMed

• PHASE3COMPLETED
  A Study of Cabozantinib (XL184) vs Everolimus in Subjects With Metastatic Renal Cell CarcinomaExelixis · NCT01865747
• NACOMPLETED
  The Role of Atorvastatin on Monocyte Function in Patients With Coronary Artery Disease and HypercholesterolemiaUniversity of Ulm · NCT00329069
• PHASE1/PHASE2COMPLETED
  Safety Study of Autologous Bone Marrow Stromal Cells With Modification by Hepatocyte Growth Factor to Treat SilicosisWei Yu · NCT01977131
• NANOT_YET_RECRUITING
  Using Autologous Bone Marrow Cells With Wharton Gel Exosomes to Stimulate Hepatic Cell Repair in Liver CirrhosisGlobal Stem Cell Center, Baghdad · NCT07374185
• PHASE3RECRUITING
  Phase 3 Study of KP-100LI in Subjects With Vocal Fold ScarKringle Pharma, Inc. · NCT05627648
• COMPLETED
  Hepatocyte Growth Factor and Cardiovascular Autonomic FunctionOita Red Cross Hospital · NCT00478127

via ClinicalTrials.gov

Wikidata facts

Instance of

protein

Image

Protein HGF PDB 1bht.png

via Wikidata · CC0