Structure via PubChem · Public domain (PubChem)
iloperidone
Sign in to saveAlso known as ILO522, HP-873, 1-[4-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1- piperidinyl]propoxy]-3-methoxyphenyl]ethanone, 4'-{3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino]propoxy}-3'-methoxyacetophenone
Iloperidone, sold under the brand name Fanapt among others, is an atypical antipsychotic for the treatment of schizophrenia and bipolar I disorder.
Chemical data
- Formula
- C24H27FN2O4
- Molecular weight
- 426.5 g/mol
- IUPAC name
- 1-[4-[3-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]propoxy]-3-methoxyphenyl]ethanone
- SMILES
- CC(=O)C1=CC(=C(C=C1)OCCCN2CCC(CC2)C3=NOC4=C3C=CC(=C4)F)OC
- InChIKey
- XMXHEBAFVSFQEX-UHFFFAOYSA-N
- XLogP
- 4.1
- Polar surface area
- 64.8 Ų
- H-bond donors
- 0
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2009
- Admin. routes
- oral
- Indications
- liver disease, post-traumatic stress disorder, psychosis, bipolar I disorder
via ChEMBL · EBI
Research
265 papers- Iloperidone.2012
- Iloperidone.2006
- Iloperidone for the management of adults with schizophrenia.Clinical therapeutics · 2011
- Iloperidone for the treatment of schizophrenia.Drugs of today (Barcelona, Spain : 1998) · 2010
- Iloperidone: a clinical overview.The Journal of clinical psychiatry · 2011
via PubMed
Wikidata facts
- Subclass of
- heterocyclic compound
- Has part
- carbon
- Mass
- 426.195486
- Has use
- medication
Show 8 more facts
- chemical formula
- C₂₄H₂₇FN₂O₄
- canonical SMILES
- CC(=O)C1=CC(=C(C=C1)OCCCN2CCC(CC2)C3=NOC4=C3C=CC(=C4)F)OC
- World Health Organisation international non-proprietary name
- iloperidone
- defined daily dose
- 18
- Commons category
- Iloperidone
- subject has role
- antipsychotics
- medical condition treated
- schizophrenia
- legal status (medicine)
- boxed warning
Sources (8)
via Wikidata · CC0
~4 min read
Encyclopedic overview
8 sectionsContents
- Medical uses
- Side effects
- Withdrawal
- Pharmacology
- History
- See also
- References
- External links
Iloperidone, sold under the brand name Fanapt among others, is an atypical antipsychotic for the treatment of schizophrenia and bipolar I disorder.
==Medical uses== Iloperidone is indicated for the treatment of schizophrenia and mania or mixed episodes in bipolar I disorder. In a 2013 study in a comparison of 15 antipsychotic drugs in effectivity in treating schizophrenic symptoms, iloperidone demonstrated mild effectiveness — as effective as lurasidone, and 13 to 15% less effective than ziprasidone, chlorpromazine, and asenapine. It generally appears to work better than placebo.
Excerpted from Wikipedia’s “iloperidone” article, available under the CC BY-SA 4.0 licence.