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GeneQ18036042· pop 6· linked from 386 articles

LILRA2

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Also known as CD85H, ILT1, LIR-7, LIR7, leukocyte immunoglobulin like receptor A2

Leukocyte immunoglobulin-like receptor subfamily A member 2 (LILRA2, CD85H, ILT1) is a protein that in humans is encoded by the LILRA2 gene.

Gene data

LILRA2
Name
leukocyte immunoglobulin like receptor A2
Type
protein-coding
Position
54,572,920–54,590,287 (+)
Aliases
CD85H, ILT1, LIR-7, LIR7
Ensembl
ENSG00000278634
RefSeq RNA
NM_001130917.3, NM_001290270.1, NM_001290271.2, NM_006866.4, XM_011526390.2
RefSeq protein
NP_001124389.2, NP_001277199.1, NP_001277200.1, NP_006857.2, XP_011524692.1

This gene encodes a member of a family of immunoreceptors that are expressed predominantly on monocytes and B cells, and at lower levels on dendritic cells and natural killer cells. The encoded protein is an activating receptor that inhibits dendritic cell differentiation and antigen presentation and suppresses innate immune response. Alternatively spliced transcript variants encoding different isoforms have been found. This gene is located in a cluster of related genes on chromosome 19 and there is a pseudogene for this gene on chromosome 3. [provided by RefSeq, Mar 2014].

Gene Ontology

Pathways

Osteoclast differentiation - Homo sapiens (human)B cell receptor signaling pathway - Homo sapiens (human)Adaptive Immune SystemImmune SystemImmunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

via MyGene.info

Gene · Ensembl

leukocyte immunoglobulin like receptor A2

Symbol
LILRA2
Biotype
Protein coding
Organism
Homo sapiens
Location
19:54,572,920-54,590,287
Strand
Forward (+)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

~1 min read

Encyclopedic overview

5 sections
Contents
  • Function
  • See also
  • References
  • Further reading
  • External links

Leukocyte immunoglobulin-like receptor subfamily A member 2 (LILRA2, CD85H, ILT1) is a protein that in humans is encoded by the LILRA2 gene.

Leukocyte Ig-like receptors (LIRs) are a family of immunoreceptors expressed predominantly on monocytes and B cells and at lower levels on dendritic cells and natural killer (NK) cells. All LIRs in subfamily B have an inhibitory function (see, e.g., LILRB1, MIM 604811). LIRs in subfamily A, with short cytoplasmic domains lacking an immunoreceptor tyrosine-based inhibitory motif (ITIM) and with transmembrane regions containing a charged arginine residue, may initiate stimulatory cascades. One member of subfamily A (LILRA3; MIM 604818) lacks a transmembrane region and is presumed to be a soluble receptor.[supplied by OMIM]

Excerpted from Wikipedia’s “LILRA2” article, available under the CC BY-SA 4.0 licence.

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