MAPKAPK3

Name

MAPK activated protein kinase 3

Type

protein-coding

Position

50,611,487–50,651,017 (+)

Aliases

3PK, MAPKAP-K3, MAPKAP3, MAPKAPK-3, MDPT3, MK-3, MK3

Ensembl

ENSG00000114738

RefSeq RNA

NM_001243925.2, NM_001243926.2, NM_004635.5, XM_047448883.1, XM_047448884.1

RefSeq protein

NP_001230854.1, NP_001230855.1, NP_004626.1, XP_047304839.1, XP_047304840.1

This gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011].

via MyGene.info

Gene · Ensembl

MAPK activated protein kinase 3

Symbol

MAPKAPK3

Biotype

Protein coding

Organism

Homo sapiens

Location

3:50,611,487-50,651,017

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

Protein MAPKAPK3 PDB 3FHR.png

via Wikidata · CC0