MAP3K2
Sign in to saveAlso known as MEKK2, MEKK2B, mitogen-activated protein kinase kinase kinase 2
Mitogen-Activated Protein Kinase Kinase Kinase 2 also known as MEKK2 (MEK/ERK Kinase 2) is an enzyme that in humans is encoded by the MAP3K2 gene.
In the Vinony graph
Vinony's link graph records 304 inbound references to MAP3K2, and connects out to protein-serine-threonine kinases, PubMed and human chromosome 2.
It is catalogued under topics including EC 2.7.11, Genes on human chromosome 2 and Long stubs with short prose.
Vinony links it to 5 Wikipedia language editions.
Gene data
MAP3K2- Name
- mitogen-activated protein kinase kinase kinase 2
- Type
- protein-coding
- Position
- 127,298,668–127,388,465 (−)
- Aliases
- MEKK2, MEKK2B
- Ensembl
- ENSG00000169967
- RefSeq RNA
- NM_001371910.2, NM_001371911.1, NM_006609.5, XM_047442989.1, XM_047442990.1
- RefSeq protein
- NP_001358839.1, NP_001358840.1, NP_006600.3, XP_047298945.1, XP_047298946.1
The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
mitogen-activated protein kinase kinase kinase 2
- Symbol
- MAP3K2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:127,298,668-127,388,465
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein MAP3K2 PDB 2cu1.png
Show 8 more facts
- HomoloGene ID
- 74576
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/10746
- genomic end
- 128146041
- genomic start
- 127298668
- chromosome
- human chromosome 2
- cytogenetic location
- 2q14.3
- expressed in
- pylorus
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
5 sectionsContents
- Function
- Activation
- Interactions
- References
- Further reading
Mitogen-Activated Protein Kinase Kinase Kinase 2 also known as MEKK2 (MEK/ERK Kinase 2) is an enzyme that in humans is encoded by the MAP3K2 gene.
== Function ==
Excerpted from Wikipedia’s “MAP3K2” article, available under the CC BY-SA 4.0 licence.