mebeverine

Also known as CSAG-144

Mebeverine is a drug used to alleviate some of the symptoms of irritable bowel syndrome. It works by relaxing the muscles in and around the gut.

Chemical data

Formula: C25H35NO5
Molecular weight: 429.5 g/mol
IUPAC name: 4-[ethyl-[1-(4-methoxyphenyl)propan-2-yl]amino]butyl 3,4-dimethoxybenzoate
SMILES: CCN(CCCCOC(=O)C1=CC(=C(C=C1)OC)OC)C(C)CC2=CC=C(C=C2)OC
InChIKey: VYVKHNNGDFVQGA-UHFFFAOYSA-N
XLogP: 5.2
Polar surface area: 57.2 Å²
H-bond donors: 0
H-bond acceptors: 6
Formal charge: 0

via PubChem

Research

233 papers

The Efficacy of Mebeverine in the Treatment of Irritable Bowel Syndrome-A Systematic Review.Journal of clinical medicine · 2022
Mebeverine and the Influence of Labeling in Adolescents With Irritable Bowel Syndrome or Functional Abdominal Pain Not Otherwise Specified: A 2 × 2 Randomized, Placebo-Controlled Trial.Gastroenterology · 2025
Clinical efficacy of mebeverine for persistent nocturnal enuresis after orthotopic W-neobladder.BJU international · 2022
A systematic review of efficacy and tolerability of mebeverine in irritable bowel syndrome.World journal of gastroenterology · 2010
[Development of selective method for identifying mebeverine in hair].Sudebno-meditsinskaia ekspertiza · 2024

via PubMed

Wikidata facts

Mass: 429.252

Show 3 more facts

Commons category: Mebeverine
chemical formula: C₂₅H₃₅NO₅
canonical SMILES: CCN(CCCCOC(=O)C1=CC(=C(C=C1)OC)OC)C(C)CC2=CC=C(C=C2)OC

Sources (2)

via Wikidata · CC0

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Article

8 sections

Contents

Medical use
Adverse effects
Pharmacology
Mechanism of action
Pharmacokinetics
History
Availability
References

Mebeverine is a drug used to alleviate some of the symptoms of irritable bowel syndrome. It works by relaxing the muscles in and around the gut.

==Medical use== Mebeverine is used to alleviate some of the symptoms of irritable bowel syndrome (IBS) and related conditions; specifically stomach pain and cramps, persistent diarrhoea, and flatulence.