Melperone

Key facts

Drug.verifiedrevid

447616990

Drug.IUPAC_name

1-(4-fluorophenyl)-4-(4-methylpiperidin-1-yl)butan-1-one

Drug.image

Melperone.svg

Drug.image_class

skin-invert-image

Drug.alt

Skeletal formula of melperone

Drug.width

250

Drug.image2

Melperone 3D ball.png

Drug.image_class2

bg-transparent

Drug.alt2

Space-filling model of the melperone molecule

Drug.width2

250

Drug.tradename

Buronil

Drug.legal_status

Rx-only

Drug.routes_of_administration

Oral, intramuscular injection

Drug.bioavailability

87% (IM), 54% (Oral via syrup), 65% (Oral, tablet)

Drug.protein_bound

50%

Drug.metabolism

Hepatic

Drug.elimination_half life

3–4 hours (oral)6 hours (IM)

Drug.excretion

Renal (70% as metabolites, 5.5–10.4% as unchanged drug)

via Wikipedia infobox

Chemical data

Formula

C16H22FNO

Molecular weight

263.35 g/mol

IUPAC name

1-(4-fluorophenyl)-4-(4-methylpiperidin-1-yl)butan-1-one

SMILES

CC1CCN(CC1)CCCC(=O)C2=CC=C(C=C2)F

InChIKey

DKMFBWQBDIGMHM-UHFFFAOYSA-N

XLogP

3.3

Polar surface area

20.3 Ų

H-bond donors

0

H-bond acceptors

3

Formal charge

0

via PubChem

Drug data · ChEMBL

Max clinical phase

Phase 3

Molecule type

Small molecule

Indications

psychosis, anxiety, Dementia, depressive disorder

via ChEMBL · EBI

• Interpretation of melperone intoxication: post-mortem concentration distribution and interpretation of intoxication data.Drug metabolism and personalized therapy · 2021
• Zuclopenthixol, melperone and haloperidol/levomepromazine in the elderly. Meta-analysis of two double-blind trials at 15 nursing homes in Norway.Current medical research and opinion · 1992
• Melperone in the treatment of neuroleptic-resistant schizophrenia.Psychiatry research · 2001
• Melperone in the treatment of schizophrenia.Acta psychiatrica Scandinavica. Supplementum · 1989
• Melperone, an aytpical antipsychotic drug with clozapine-like effect on plasma prolactin: contrast with typical neuroleptics.Human psychopharmacology · 2009

via PubMed

Wikidata facts

Subclass of

chemical compound

Mass

263.168543

Has use

medication

via Wikidata · CC0