mitotic prometaphase
Also known as GO:0000236, prometaphase
thumb|upright=1.35|Diagram of prometaphase Prometaphase is the stage of mitosis following prophase and preceding metaphase in eukaryotic somatic cells. In prometaphase, the nuclear membrane breaks apart into numerous "membrane vesicles," and the chromosomes inside form protein structures called kinetochores. Kinetochore microtubules emerging from the centrosomes at the poles (ends) of the spindle reach the chromosomes and attach to the kinetochores, throwing the chromosomes into agitated motion. Other spindle microtubules make contact with microtubules coming from the opposite pole. Forces exe
Research
932 papers- Prometaphase.Seminars in cell & developmental biology · 2021
- The first mitotic division of human embryos is highly error prone.Nature communications · 2022
- P2P-R protein overexpression restricts mitotic progression at prometaphase and promotes mitotic apoptosis.Journal of cellular physiology · 2002
- Near millimolar concentration of nucleosomes in mitotic chromosomes from late prometaphase into anaphase.The Journal of cell biology · 2024
- Mitotic chromosomes harbor cell type- and species-specific structural features within a universal loop array conformation.Genome research · 2025
via PubMed
Article
4 sectionsContents
- Types of microtubules
- Transition from prometaphase to metaphase
- References
- External links
thumb|upright=1.35|Diagram of prometaphase Prometaphase is the stage of mitosis following prophase and preceding metaphase in eukaryotic somatic cells. In prometaphase, the nuclear membrane breaks apart into numerous "membrane vesicles," and the chromosomes inside form protein structures called kinetochores. Kinetochore microtubules emerging from the centrosomes at the poles (ends) of the spindle reach the chromosomes and attach to the kinetochores, throwing the chromosomes into agitated motion. Other spindle microtubules make contact with microtubules coming from the opposite pole. Forces exerted by protein "motors" associated with spindle microtubules move the chromosomes toward the centre of the cell.
Prometaphase is not always presented as a distinct part of mitosis. In sources that do not use the term, the events described here are instead assigned to late prophase and early metaphase.