Also known as C10orf48, IFRX, IRXL1, mohawk homeobox
Homeobox protein Mohawk, also known as iroquois homeobox protein-like 1, is a protein that in humans is encoded by the MKX (mohawk homeobox) gene. MKX is a member of an Iroquois (IRX) family-related class of 'three-amino acid loop extension' (TALE) atypical homeobox proteins characterized by 3 additional amino acids in the loop region between helix I and helix II of the homeodomain.
Gene data
MKX- Name
- mohawk homeobox
- Type
- protein-coding
- Aliases
- C10orf48, IFRX, IRXL1
The protein encoded by this gene is an IRX family-related homeobox protein that may play a role in cell adhesion. Studies in mice suggest that this protein may be a regulator of tendon development. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jun 2011].
via MyGene.info
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 72239
- exact match
- identifiers.org/ncbigene/283078
- genomic end
- 28034989
- genomic start
- 27672874
- cytogenetic location
- 10p12.1
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Article
3 sectionsContents
- Function
- References
- Further reading
Homeobox protein Mohawk, also known as iroquois homeobox protein-like 1, is a protein that in humans is encoded by the MKX (mohawk homeobox) gene. MKX is a member of an Iroquois (IRX) family-related class of 'three-amino acid loop extension' (TALE) atypical homeobox proteins characterized by 3 additional amino acids in the loop region between helix I and helix II of the homeodomain.
== Function == MKX is a transcription factor that regulates tendon differentiation during embryological development. Knocking out this gene in mouse embryos results in them developing hypoplastic tendons containing less type I collagen. MKX binds directly to the promoter of MyoD and represses its expression, negatively regulating muscle differentiation.