مرفین

Key facts

Drug.verifiedrevid

477170110

Drug.image

Morphine2DCSDS.svg

Drug.image_class

skin-invert-image

Drug.width

180

Drug.image2

Morphine molecule ball.png

Drug.image_class2

bg-transparent

Drug.tradename

Statex, MS Contin, Kadian, Oramorph, M-ESLON, others

Drug.MedlinePlus

a682133

Drug.DailyMedID

Morphine

Drug.pregnancy_AU

C

Drug.dependency_liability

High

Drug.addiction_liability

High

Drug.routes_of_administration

Inhalation, insufflation, by mouth, rectal, subcutaneous, intramuscular, intravenous, epidural, intrathecal

Drug.class

Opiate

Drug.ATC_prefix

N02

Drug.ATC_suffix

AA01

Drug.legal_AU

S8

Drug.legal_BR

A1

via Wikipedia infobox

Chemical data

Formula

C17H19NO3

Molecular weight

285.34 g/mol

IUPAC name

(4R,4aR,7S,7aR,12bS)-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol

SMILES

CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)O)O[C@H]3[C@H](C=C4)O

InChIKey

BQJCRHHNABKAKU-KBQPJGBKSA-N

XLogP

0.8

Polar surface area

52.9 Ų

H-bond donors

2

H-bond acceptors

4

Formal charge

0

via PubChem

• Morphine metabolites.ReviewActa anaesthesiologica Scandinavica · 1997Christrup LLDOI: 10.1111/j.1399-6576.1997.tb04625.x
• Pharmacological data science perspective on fatal incidents of morphine treatment.ReviewPharmacology & therapeutics · 2023Noufal Y, Kringel D, Toennes SW et al.DOI: 10.1016/j.pharmthera.2022.108312
• Morphine-6-glucuronide: morphine's successor for postoperative pain relief?ReviewAnesthesia and analgesia · 2006van Dorp EL, Romberg R, Sarton E et al.DOI: 10.1213/01.ane.0000217197.96784.c3
• Morphine pharmacokinetics and analgesia after oral administration.ReviewPostgraduate medical journal · 1991Hanks GW
• Role of morphine's metabolites in analgesia: concepts and controversies.ReviewThe AAPS journal · 2006Wittwer E, Kern SEDOI: 10.1007/BF02854905
• Considerations in morphine therapy.ReviewAmerican journal of hospital pharmacy · 1994Laizure SC
• The role of morphine glucuronides in cancer pain.ReviewPalliative medicine · 1999Mercadante SDOI: 10.1191/026921699678158579
• A review of morphine and morphine-6-glucuronide's pharmacokinetic-pharmacodynamic relationships in experimental and clinical pain.ReviewEuropean journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2015Sverrisdóttir E, Lund TM, Olesen AE et al.DOI: 10.1016/j.ejps.2015.03.020

via PubMed