Structure via PubChem · Public domain (PubChem)
naphazoline
Also known as Naphcon®, Nafazolin, PRV942
Naphazoline is a medicine used as a decongestant, and a vasoconstrictor added to eye drops to relieve red eye. It has a rapid action in reducing swelling when applied to mucous membranes. It is a sympathomimetic agent with marked alpha adrenergic activity that acts on alpha-receptors in the arterioles of the conjunctiva to produce constriction, resulting in decreased congestion.
Chemical data
- Formula
- C14H14N2
- Molecular weight
- 210.27 g/mol
- IUPAC name
- 2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole
- SMILES
- C1CN=C(N1)CC2=CC=CC3=CC=CC=C32
- InChIKey
- CNIIGCLFLJGOGP-UHFFFAOYSA-N
- XLogP
- 2.1
- Polar surface area
- 24.4 Ų
- H-bond donors
- 1
- H-bond acceptors
- 1
- Formal charge
- 0
via PubChem
~3 min read
Article
12 sectionsContents
- Medical uses
- Nasal administration
- Ophthalmic drug administration
- Side effects
- Nasal administration
- Ophthalmic drug administration
- Contraindications
- Pharmacology
- Chemistry
- Society and culture
- Illicit use
- References
Naphazoline is a medicine used as a decongestant, and a vasoconstrictor added to eye drops to relieve red eye. It has a rapid action in reducing swelling when applied to mucous membranes. It is a sympathomimetic agent with marked alpha adrenergic activity that acts on alpha-receptors in the arterioles of the conjunctiva to produce constriction, resulting in decreased congestion.
It was patented in 1934 and came into medical use in 1942.
Gallery (2)
Connections
Categories
1-Naphthyl compoundsAlpha1-adrenergic agonistsAlpha2-adrenergic agonistsDecongestantsDrugboxes which contain changes to verified fieldsDrugboxes which contain changes to watched fieldsDrugs with non-standard legal statusECHA InfoCard ID from WikidataImidazolinesNaphthylethylaminesOphthalmology drugsOver-the-counter drugs in the United States