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GeneQ18030083· pop 6· linked from 815 articles

Also known as NF-E2, p45, nuclear factor, erythroid 2

__NOTOC__ Transcription factor NF-E2 45 kDa subunit is a protein that in humans is encoded by the NFE2 gene.

Gene data

NFE2
Name
nuclear factor, erythroid 2
Type
protein-coding
Position
54,292,107–54,301,259 (−)
Aliases
NF-E2, p45
RefSeq RNA
NM_001136023.3, NM_001261461.2, NM_001400365.1, NM_001400372.1, NM_001400373.1
RefSeq protein
NP_001129495.1, NP_001248390.1, NP_001387294.1, NP_001387301.1, NP_001387302.1

Enables several functions, including WW domain binding activity; identical protein binding activity; and protein N-terminus binding activity. Contributes to cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including labyrinthine layer blood vessel development; negative regulation of bone mineralization; and negative regulation of syncytium formation by plasma membrane fusion. Part of protein-DNA complex. [provided by Alliance of Genome Resources, Apr 2022]

via MyGene.info

Wikidata facts

Image
Protein NFE2 PDB 1LVX.png
Show 5 more facts
HomoloGene ID
4491
genomic end
54301015
genomic start
54685895
cytogenetic location
12q13.13
Sources (4)

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__NOTOC__ Transcription factor NF-E2 45 kDa subunit is a protein that in humans is encoded by the NFE2 gene.

It is involved in megakaryocyte production.

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