نيسرغولين

Key facts

Drug.Verifiedfields

changed

Drug.verifiedrevid

462260029

Drug.IUPAC_name

[(6aR,9R,10aS)-10a-methoxy-4,7-dimethyl-6a,8,9,10-tetrahydro-6H-indolo[4,3-fg]quinolin-9-yl]methyl 5-bromopyridine-3-carboxylate

Drug.image

Nicergoline Structure V.1.svg

Drug.image_class

skin-invert-image

Drug.width

200px

Drug.tradename

Sermion

Drug.pregnancy_category

Not recommended

Drug.routes_of_administration

By mouth, intramuscular, intravenous

Drug.ATC_prefix

C04

Drug.ATC_suffix

AE02

Drug.legal_EU

Rx-only

Drug.bioavailability

<5%

Drug.protein_bound

>90%

Drug.metabolism

Extensive First-pass metabolism

Drug.elimination_half life

13–20 hours

Drug.CAS_number

27848-84-6

Drug.PubChem

34040

via Wikipedia infobox

Chemical data

Formula

C24H26BrN3O3

Molecular weight

484.4 g/mol

IUPAC name

[(6aR,9R,10aS)-10a-methoxy-4,7-dimethyl-6a,8,9,10-tetrahydro-6H-indolo[4,3-fg]quinolin-9-yl]methyl 5-bromopyridine-3-carboxylate

SMILES

CN1C[C@@H](C[C@]2([C@H]1CC3=CN(C4=CC=CC2=C34)C)OC)COC(=O)C5=CC(=CN=C5)Br

InChIKey

YSEXMKHXIOCEJA-FVFQAYNVSA-N

XLogP

3.2

Polar surface area

56.6 Ų

H-bond donors

0

H-bond acceptors

5

Formal charge

0

via PubChem

Drug data · ChEMBL

Max clinical phase

Approved

Molecule type

Small molecule

Indications

cardiovascular disease, anxiety, Dementia, depressive disorder

via ChEMBL · EBI

• Therapeutic use of nicergoline.Clinical drug investigation · 2008
• Ergotamine and nicergoline - facts and myths.Pharmacological reports : PR · 2015
• Safety of nicergoline as an agent for management of cognitive function disorders.BioMed research international · 2014
• Apoptosis in Alzheimer's disease: insight into the signaling pathways and therapeutic avenues.Apoptosis : an international journal on programmed cell death · 2023
• Neurotrophic keratopathy: current challenges and future prospects.Annals of medicine · 2022

via PubMed

Wikidata facts

Mass

483.115754

Has use

medication

via Wikidata · CC0