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GeneQ15312256· pop 6· linked from 817 articles

NR4A2

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Also known as HZF-3, NOT, NURR1, RNR1, TINUR, nuclear receptor subfamily 4 group A member 2

protein-coding gene in the species Homo sapiens

In the Vinony graph

Within Vinony's link graph, NR4A2 is referenced by 817 other articles, and connects out to PubMed, homeobox and Ensembl genome database project.

Vinony files it under Genes on human chromosome 2, Intracellular receptors and Transcription factors.

Its subject is documented across 6 Wikipedia language editions.

Gene data

NR4A2

Name: nuclear receptor subfamily 4 group A member 2
Type: protein-coding
Position: 156,324,432–156,342,348 (−)
Aliases: HZF-3, IDLDP, NOT, NURR1, RNR1, TINUR
Ensembl: ENSG00000153234
RefSeq RNA: NM_001446169.1, NM_001446170.1, NM_001446171.1, NM_001446172.1, NM_001446173.1
RefSeq protein: NP_001433098.1, NP_001433099.1, NP_001433100.1, NP_001433101.1, NP_001433102.1

This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II neuron migration DNA-templated transcription DNA-templated transcription regulation of DNA-templated transcription regulation of transcription by RNA polymerase II central nervous system neuron differentiation

Molecular function

RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA binding

Cellular component

chromatin nucleus nucleus nucleus nucleus nucleus nucleoplasm transcription regulator complex

Pathways

Aldosterone synthesis and secretion - Homo sapiens (human)Parathyroid hormone synthesis, secretion and action - Homo sapiens (human)Generic Transcription Pathway SUMOylation SUMO E3 ligases SUMOylate target proteins Nuclear Receptor transcription pathway Metabolism of proteins SUMOylation of intracellular receptors Post-translational protein modification RNA Polymerase II Transcription

via MyGene.info

Gene · Ensembl

nuclear receptor subfamily 4 group A member 2

Symbol: NR4A2
Biotype: Protein coding
Organism: Homo sapiens
Location: 2:156,324,432-156,342,348
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein NR4A2 PDB 1cit.png

Show 7 more facts

HomoloGene ID: 4509
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/4929
genomic end: 157198860
genomic start: 156324437
chromosome: human chromosome 2
cytogenetic location: 2q24.1

Sources (3)

via Wikidata · CC0

Available in 6 languages

via Wikidata sitelinks · CC0

Categories

Genes on human chromosome 2 Intracellular receptors Transcription factors