perazine

Perazine (Taxilan) is a moderate-potency typical antipsychotic of the phenothiazine class. It is quite similar to chlorpromazine, and acts as a dopamine antagonist. It was very popular in West-Germany. A 2014 systematic review compared it with other antipsychotic drugs: {| class="wikitable" |+ Perazine versus other antipsychotic drugs for schizophrenia |- ! Summary |- | The number, size and reporting of randomized controlled perazine trials are insufficient to present firm conclusions about the properties of this antipsychotic. It is possible that perazine is associated with a similar risk of extrapyramidal side effects as some atypical antipsychotics but this is based on few comparisons of limited power. |- | style="padding:0;" | {| class="wikitable collapsible collapsed" style="width:100%;" |- ! scope="col" style="text-align: left;"| Outcome ! scope="col" style="text-align: left;"| Findings in words ! scope="col" style="text-align: left;"| Findings in numbers ! scope="col" style="text-align: left;"| Quality of evidence |- ! colspan="4" style="text-align: left;"| Global state |- | No better or deteriorationFollow-up: average 5 weeks|| Perazine may decrease the chance of experiencing this outcome. These findings are based on data of low quality.|| RR 0.43 (0.23 to 0.81) || Low |- ! colspan="4" style="text-align: left;"| Mental state |- | Less than 30% BPRS reductionFollow-up: mean 5 weeks ||The average overall mental state score in the perazine group was lower than for those given other antipsychotic drugs but the difference between the groups was not clear. These findings are based on data of low quality. || RR 0.82 (0.61 to 1.09) || Low |- ! colspan="4" style="text-align: left;"| Adverse effects |- | Needing antiparkinson medicationFollow-up: average 5 weeks || Perazine might increase the risk of experiencing this outcome but at present it is not possible to be confident about the difference between perazine and other antipsychotic drugs. Data supporting this finding are very limited. || RR 4.5 (1.04 to 19.45) || Very low |- |Leaving the study early - due to adverse eventsFollow-up: average 4 weeks || There was not a clear difference between perazine and the other antipsychotic drugs for this general outcome reflecting overall adverse event 'load'. These findings are based on data of low quality.|| 0.87 (0.4 to 1.9) || Low |- ! colspan="4" style="text-align: left;"| Acceptability of treatment |- | Leaving the studies early - any reasonFollow-up: 5 weeks || Perazine and the comparison antipsychotic drugs were equally tolerated. These findings are based on data of low quality.|| RR 0.62 (0.35 to 1.1) || Low |- | || No study reported any data on outcomes such as quality of life or information relating to satisfaction with care. || || |} |}

==Synthesis== thumb|center|501px|class=skin-invert-image|Perazine synthesis: Patents: Alternate source: