Structure via PubChem · Public domain (PubChem)
remikiren
Sign in to saveRemikiren is a renin inhibitor under development for the treatment of hypertension (high blood pressure). It was first developed by Hoffmann–La Roche in 1996.
Chemical data
- Formula
- C33H50N4O6S
- Molecular weight
- 630.8 g/mol
- IUPAC name
- (2S)-2-benzyl-3-tert-butylsulfonyl-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohexyl-4-cyclopropyl-3,4-dihydroxybutan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]propanamide
- SMILES
- CC(C)(C)S(=O)(=O)C[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N[C@@H](CC3CCCCC3)[C@H]([C@H](C4CC4)O)O
- InChIKey
- UXIGZRQVLGFTOU-VQXQMPIVSA-N
- XLogP
- 4
- Polar surface area
- 170 Ų
- H-bond donors
- 5
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- cardiovascular disease
via ChEMBL · EBI
Research
68 papers- Discovery of remikiren as the first orally active renin inhibitor.Arzneimittel-Forschung · 1993
- Remikiren (Ro 42-5892)--an orally active renin inhibitor in essential hypertension. Effects on blood pressure and the renin-angiotensin-aldosterone system.American journal of hypertension · 1996
- Distribution of remikiren, a potent orally active inhibitor of human renin, in laboratory animals.Xenobiotica; the fate of foreign compounds in biological systems · 1996
- Interaction of the renin inhibitor aliskiren with the SARS-CoV-2 main protease: a molecular docking study.Journal of biomolecular structure & dynamics · 2022
- Excretion and metabolism of remikiren, a potent orally active inhibitor of primate renin.Xenobiotica; the fate of foreign compounds in biological systems · 1996
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 630.345
- Has use
- medication
Show 5 more facts
- chemical formula
- C₃₃H₅₀N₄O₆S
- World Health Organisation international non-proprietary name
- remikiren
- isomeric SMILES
- CC(C)(C)S(=O)(=O)C[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N[C@@H](CC3CCCCC3)[C@H]([C@H](C4CC4)O)O
- canonical SMILES
- CC(C)(C)S(=O)(=O)CC(CC1=CC=CC=C1)C(=O)NC(CC2=CN=CN2)C(=O)NC(CC3CCCCC3)C(C(C4CC4)O)O
- subject has role
- protease inhibitor
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Remikiren is a renin inhibitor under development for the treatment of hypertension (high blood pressure). It was first developed by Hoffmann–La Roche in 1996.
==References==
Excerpted from Wikipedia’s “remikiren” article, available under the CC BY-SA 4.0 licence.