remikiren
Sign in to saveRemikiren is a renin inhibitor under development for the treatment of hypertension (high blood pressure). It was first developed by Hoffmann–La Roche in 1996.
Research
68 papers- Discovery of remikiren as the first orally active renin inhibitor.Arzneimittel-Forschung · 1993
- Remikiren (Ro 42-5892)--an orally active renin inhibitor in essential hypertension. Effects on blood pressure and the renin-angiotensin-aldosterone system.American journal of hypertension · 1996
- Distribution of remikiren, a potent orally active inhibitor of human renin, in laboratory animals.Xenobiotica; the fate of foreign compounds in biological systems · 1996
- Interaction of the renin inhibitor aliskiren with the SARS-CoV-2 main protease: a molecular docking study.Journal of biomolecular structure & dynamics · 2022
- Excretion and metabolism of remikiren, a potent orally active inhibitor of primate renin.Xenobiotica; the fate of foreign compounds in biological systems · 1996
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 630.345
- Has use
- medication
Show 5 more facts
- chemical formula
- C₃₃H₅₀N₄O₆S
- World Health Organisation international non-proprietary name
- remikiren
- isomeric SMILES
- CC(C)(C)S(=O)(=O)C[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N[C@@H](CC3CCCCC3)[C@H]([C@H](C4CC4)O)O
- canonical SMILES
- CC(C)(C)S(=O)(=O)CC(CC1=CC=CC=C1)C(=O)NC(CC2=CN=CN2)C(=O)NC(CC3CCCCC3)C(C(C4CC4)O)O
- subject has role
- protease inhibitor
Sources (2)
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Encyclopedic overview
1 sectionsContents
- References
Remikiren is a renin inhibitor under development for the treatment of hypertension (high blood pressure). It was first developed by Hoffmann–La Roche in 1996.
==References==
Excerpted from Wikipedia’s “remikiren” article, available under the CC BY-SA 4.0 licence.