Structure via PubChem · Public domain (PubChem)
(RS)-propafenone
Sign in to saveAlso known as GNF-Pf-4594, 2-(2'-hydroxy-3'-propylaminopropoxy)-omega-phenylpropiophenone, 1-{2-[2-hydroxy-3-(propylamino)propoxy]phenyl}-3-phenyl-1-propanone
Propafenone, sold under the brand name Rythmol among others, is a class 1c anti-arrhythmic medication, which is used to treat illnesses associated with rapid heart beat such as atrial and ventricular arrhythmias.
Chemical data
- Formula
- C21H27NO3
- Molecular weight
- 341.4 g/mol
- IUPAC name
- 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one
- SMILES
- CCCNCC(COC1=CC=CC=C1C(=O)CCC2=CC=CC=C2)O
- InChIKey
- JWHAUXFOSRPERK-UHFFFAOYSA-N
- XLogP
- 3.3
- Polar surface area
- 58.6 Ų
- H-bond donors
- 2
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Research
1 papersvia PubMed
Wikidata facts
- Subclass of
- medication
- Mass
- 341.199
Show 6 more facts
- chemical formula
- C₂₁H₂₇NO₃
- significant drug interaction
- lidocaine
- medical condition treated
- supraventricular tachycardia
- canonical SMILES
- CCCNCC(COC1=CC=CC=C1C(=O)CCC2=CC=CC=C2)O
- World Health Organisation international non-proprietary name
- propafenone
- Commons category
- Propafenone
via Wikidata · CC0
~5 min read
Encyclopedic overview
11 sectionsContents
- Mechanism of action
- Metabolism
- Side effects
- Initiation of therapy
- Contraindications and cautions
- History
- Stereochemistry
- See also
- References
- Further reading
- External links
{{drugbox | Watchedfields = changed | verifiedrevid = 464215884 | IUPAC_name = 1-{2-[2-Hydroxy-3-(propylamino)propoxy]phenyl}-3-phenylpropan-1-one | image = Propafenone Structure.svg | image_class = skin-invert-image | width = 200 | image2 = Propafenona ball-and-stick.png | image_class2 = bg-transparent | width2 = 200
| pronounce = | tradename = Rythmol, Rytmonorm, others | Drugs.com = | MedlinePlus = a698002 | DailyMedID = Propafenone | pregnancy_AU = | pregnancy_AU_comment = | pregnancy_US = N | pregnancy_US_comment = | pregnancy_category= | routes_of_administration = By mouth
Excerpted from Wikipedia’s “(RS)-propafenone” article, available under the CC BY-SA 4.0 licence.