Structure via PubChem · Public domain (PubChem)
sevoflurane
Sign in to saveAlso known as MR-6S4, MR6S4, Sojourn®, Ultane®, Sevofluran, 1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane, HFE-347mmz1
Sevoflurane, sold under the brand name Sevorane, among others, and informally known as sevo, is a sweet-smelling, nonflammable, highly fluorinated methyl isopropyl ether used as an inhalational anaesthetic for induction and maintenance of general anesthesia. After desflurane, it is the volatile anesthetic with the fastest onset. While its offset may be faster than agents other than desflurane in a few circumstances, its offset is more often similar to that of the much older agent isoflurane. While sevoflurane is only half as soluble as isoflurane in blood, the tissue blood partition coefficien
Key facts
- Drug.class
- Anesthetic
- Drug.Verifiedfields
- changed
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 464389790
- Drug.image
- Sevoflurane.svg
- Drug.image_class
- skin-invert-image
- Drug.image2
- Sevoflurane-3D-balls.png
- Drug.image_class2
- bg-transparent
- Drug.tradename
- Ultane, others
- Drug.pregnancy_AU
- B2
- Drug.routes_of_administration
- Inhalation
- Drug.ATC_prefix
- N01
- Drug.ATC_suffix
- AB08
- Drug.legal_AU
- S4
- Drug.legal_BR
- C1
- Drug.legal_CA
- Rx-only
- Drug.legal_UK
- POM
- Drug.legal_US
- Rx-only
via Wikipedia infobox
Chemical data
- Formula
- C4H3F7O
- Molecular weight
- 200.05 g/mol
- IUPAC name
- 1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy)propane
- SMILES
- C(OC(C(F)(F)F)C(F)(F)F)F
- InChIKey
- DFEYYRMXOJXZRJ-UHFFFAOYSA-N
- XLogP
- 2.8
- Polar surface area
- 9.2 Ų
- H-bond donors
- 0
- H-bond acceptors
- 8
- Formal charge
- 0
via PubChem
Research
12,717 papers- Mechanistic insight into sevoflurane-associated developmental neurotoxicity.Cell biology and toxicology · 2022
- Protective effect of sevoflurane on myocardial ischemia-reperfusion injury: a systematic review and meta-analysis.International journal of surgery (London, England) · 2024
- The protective effects of sevoflurane on subarachnoid hemorrhage.Medical gas research · 2024
- Sevoflurane: are there differences in products?Anesthesia and analgesia · 2007
- Induction of anesthesia with sevoflurane in children: Curiosities and controversies.Paediatric anaesthesia · 2022
via PubMed
~7 min read
Encyclopedic overview
9 sectionsContents
- Medical uses
- Physiological effects
- Adverse effects
- Pharmacology
- History
- Global-warming potential
- Degradation
- References
- Further reading
Sevoflurane, sold under the brand name Sevorane, among others, and informally known as sevo, is a sweet-smelling, nonflammable, highly fluorinated methyl isopropyl ether used as an inhalational anaesthetic for induction and maintenance of general anesthesia. After desflurane, it is the volatile anesthetic with the fastest onset. While its offset may be faster than agents other than desflurane in a few circumstances, its offset is more often similar to that of the much older agent isoflurane. While sevoflurane is only half as soluble as isoflurane in blood, the tissue blood partition coefficients of isoflurane and sevoflurane are quite similar. For example, in the muscle group: isoflurane 2.62 vs. sevoflurane 2.57. In the fat group: isoflurane 52 vs. sevoflurane 50. As a result, the longer the case, the more similar will be the emergence times for sevoflurane and isoflurane.
It is on the World Health Organization's List of Essential Medicines.
Excerpted from Wikipedia’s “sevoflurane” article, available under the CC BY-SA 4.0 licence.