SOX10

Also known as DOM, PCWH, WS2E, WS4, WS4C, SRY-box 10, SRY-box transcription factor 10, SOX-10

Transcription factor SOX-10 is a protein that in humans is encoded by the SOX10 gene.

In the Vinony graph

Within Vinony's link graph, SOX10 is referenced by 913 other articles, and connects out to PubMed, Sex determining region Y and Waardenburg's syndrome.

It is catalogued under topics including Genes on human chromosome 22 and Transcription factors.

Its subject is documented across 6 Wikipedia language editions.

Gene data

SOX10

Name: SRY-box transcription factor 10
Type: protein-coding
Position: 37,970,686–37,987,422 (−)
Aliases: DOM, PCWH, SOX-10, WS2E, WS4, WS4C
Ensembl: ENSG00000100146
RefSeq RNA: NM_006941.4
RefSeq protein: NP_008872.1

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II neural crest cell migration neural crest cell migration morphogenesis of an epithelium regulation of DNA-templated transcription regulation of transcription by RNA polymerase II transcription elongation by RNA polymerase II peripheral nervous system development

Molecular function

transcription cis-regulatory region binding transcription cis-regulatory region binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity

Cellular component

chromatin chromatin nucleus nucleus nucleus nucleus nucleus nucleoplasm

Pathways

Developmental Biology Developmental Biology Cell-Cell communication Adherens junctions interactions Cell-cell junction organization Cell junction organization EGR2 and SOX10-mediated initiation of Schwann cell myelination EGR2 and SOX10-mediated initiation of Schwann cell myelination Nervous system development Nervous system development

via MyGene.info

Gene · Ensembl

SRY-box transcription factor 10

Symbol: SOX10
Biotype: Protein coding
Organism: Homo sapiens
Location: 22:37,970,686-37,987,422
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 5055
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/6663
genomic end: 38383429
genomic start: 38366693
chromosome: human chromosome 22
cytogenetic location: 22q13.1
expressed in: parotid gland

Sources (7)

via Wikidata · CC0

~3 min read

Encyclopedic overview

8 sections

Contents

Function
Mutations
Immunostain
Interactions
See also
References
Further reading
External links

Transcription factor SOX-10 is a protein that in humans is encoded by the SOX10 gene.

== Function == This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and determination of cell fate. The encoded protein acts as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development.

Excerpted from Wikipedia’s “SOX10” article, available under the CC BY-SA 4.0 licence.