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GeneQ18034393· pop 5· linked from 811 articles

SOX13

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Also known as ICA12, Sox-13, SRY-box 13, SRY-box transcription factor 13

Transcription factor SOX-13 is a protein that in humans is encoded by the SOX13 gene.

In the Vinony graph

Vinony's link graph records 811 inbound references to SOX13, and connects out to PubMed, human chromosome 1 and homeobox.

It sits within the topics Genes on human chromosome 1 and Transcription factors.

Vinony links it to 5 Wikipedia language editions.

Gene data

SOX13

Name: SRY-box transcription factor 13
Type: protein-coding
Position: 204,073,106–204,127,744 (+)
Aliases: ICA12, Sox-13
Ensembl: ENSG00000143842
RefSeq RNA: NM_005686.3, XM_005245623.4, XM_047435006.1, XM_047435007.1, XM_054339716.1
RefSeq protein: NP_005677.2, XP_005245680.1, XP_047290962.1, XP_047290963.1, XP_054195691.1

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. It has also been determined to be a type-1 diabetes autoantigen, also known as islet cell antibody 12. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II regulation of DNA-templated transcription regulation of DNA-templated transcription regulation of transcription by RNA polymerase II anatomical structure morphogenesis spinal cord oligodendrocyte cell differentiation spinal cord oligodendrocyte cell differentiation gamma-delta T cell differentiation

Molecular function

transcription cis-regulatory region binding transcription cis-regulatory region binding RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity DNA-binding transcription repressor activity

Cellular component

chromatin nucleus nucleus nucleus nucleoplasm nucleoplasm cytoplasm cytoplasm

Pathways

Signal Transduction Signaling by WNT TCF dependent signaling in response to WNT Deactivation of the beta-catenin transactivating complex

via MyGene.info

Gene · Ensembl

SRY-box transcription factor 13

Symbol: SOX13
Biotype: Protein coding
Organism: Homo sapiens
Location: 1:204,073,106-204,127,744
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein SOX13 PDB 1i11.png

Show 7 more facts

HomoloGene ID: 4159
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/9580
genomic end: 204096863
genomic start: 204042243
chromosome: human chromosome 1
cytogenetic location: 1q32.1

Sources (3)

via Wikidata · CC0

~1 min read

Encyclopedic overview

5 sections

Contents

Function
See also
References
Further reading
External links

Transcription factor SOX-13 is a protein that in humans is encoded by the SOX13 gene.

== Function ==

Excerpted from Wikipedia’s “SOX13” article, available under the CC BY-SA 4.0 licence.

Available in 5 languages

via Wikidata sitelinks · CC0

Categories

Genes on human chromosome 1 Transcription factors