English

English Deutsch Español Français Italiano Nederlands Português Svenska العربية فارسی

GeneQ18031651· pop 6· linked from 818 articles

SOX4

Sign in to save

Also known as EVI16, SRY-box 4, SRY-box transcription factor 4, CSS10

Transcription factor SOX-4 is a protein that in humans is encoded by the SOX4 gene.

In the Vinony graph

Vinony's link graph records 818 inbound references to SOX4, and connects out to PubMed, human chromosome 6 and homeobox.

It is catalogued under topics including Genes on human chromosome 6 and Transcription factors.

Vinony links it to 6 Wikipedia language editions.

Gene data

SOX4

Name: SRY-box transcription factor 4
Type: protein-coding
Position: 21,593,751–21,598,619 (+)
Aliases: CSS10, EVI16, IDDSDF
Ensembl: ENSG00000124766
RefSeq RNA: NM_003107.3
RefSeq protein: NP_003098.1

This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II pro-B cell differentiation pro-B cell differentiation mitral valve morphogenesis mitral valve morphogenesis cardiac right ventricle morphogenesis cardiac right ventricle morphogenesis

Molecular function

transcription cis-regulatory region binding transcription cis-regulatory region binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific

Cellular component

chromatin nucleus nucleus nucleus nucleoplasm nucleoplasm transcription regulator complex cytoplasm

Pathways

MicroRNAs in cancer - Homo sapiens (human)Signal Transduction Signaling by WNT TCF dependent signaling in response to WNT Deactivation of the beta-catenin transactivating complex H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity ncRNAs involved in STAT3 signaling in hepatocellular carcinoma

via MyGene.info

Gene · Ensembl

SRY-box transcription factor 4

Symbol: SOX4
Biotype: Protein coding
Organism: Homo sapiens
Location: 6:21,593,751-21,598,619
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 2338
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/6659
genomic end: 21598847
genomic start: 21593751
chromosome: human chromosome 6
cytogenetic location: 6p22.3
expressed in: thymus

Sources (5)

via Wikidata · CC0

~1 min read

Encyclopedic overview

7 sections

Contents

Function
Clinical significance
Interactions
See also
References
Further reading
External links

Transcription factor SOX-4 is a protein that in humans is encoded by the SOX4 gene.

== Function ==

Excerpted from Wikipedia’s “SOX4” article, available under the CC BY-SA 4.0 licence.

Available in 6 languages

via Wikidata sitelinks · CC0

Categories

Genes on human chromosome 6 Transcription factors