SOX12
Sign in to saveAlso known as SOX22, SRY-box 12, SRY-box transcription factor 12
SOX12 is a protein that in humans is encoded by the SOX12 gene. Sox12 belongs to the SoxC group of Sox family of transcription factors, together with Sox4 and Sox11. Sox12-null knockout mice appear normal, unlike Sox4 or Sox11 knockout mice. This probably comes from functional redundancy with Sox4 and Sox11. Sox12 is a weaker activator than both Sox4 and Sox11 in mouse.
In the Vinony graph
Vinony's link graph records 811 inbound references to SOX12, and connects out to PubMed, human chromosome 20 and Ensembl genome database project.
It is catalogued under topics including Genes on human chromosome 20 and Transcription factors.
Vinony links it to 5 Wikipedia language editions.
Gene data
SOX12- Name
- SRY-box transcription factor 12
- Type
- protein-coding
- Position
- 325,552–330,224 (+)
- Aliases
- SOX22
- Ensembl
- ENSG00000177732
- RefSeq RNA
- NM_006943.4
- RefSeq protein
- NP_008874.2
Members of the SOX family of transcription factors are characterized by the presence of a DNA-binding high mobility group (HMG) domain, homologous to the HMG box of sex-determining region Y (SRY). Forming a subgroup of the HMG domain superfamily, SOX proteins have been implicated in cell fate decisions in a diverse range of developmental processes. SOX transcription factors have diverse tissue-specific expression patterns during early development and have been proposed to act as target-specific transcription factors and/or as chromatin structure regulatory elements. The protein encoded by this gene was identified as a SOX family member based on conserved domains, and its expression in various tissues suggests a role in both differentiation and maintenance of several cell types. [provided by RefSeq, Jan 2013].
Gene Ontology
Biological process
Molecular function
Cellular component
via MyGene.info
Gene · Ensembl
SRY-box transcription factor 12
- Symbol
- SOX12
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 20:325,552-330,224
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 5057
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/6666
- genomic end
- 310865
- genomic start
- 325552
- chromosome
- human chromosome 20
- cytogenetic location
- 20p13
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
SOX12 is a protein that in humans is encoded by the SOX12 gene. Sox12 belongs to the SoxC group of Sox family of transcription factors, together with Sox4 and Sox11. Sox12-null knockout mice appear normal, unlike Sox4 or Sox11 knockout mice. This probably comes from functional redundancy with Sox4 and Sox11. Sox12 is a weaker activator than both Sox4 and Sox11 in mouse.
Members of the SOX family of transcription factors are characterized by the presence of a DNA-binding high mobility group (HMG) domain, homologous to the HMG box of sex-determining region Y (SRY). Forming a subgroup of the HMG domain superfamily, SOX proteins have been implicated in cell fate decisions in a diverse range of developmental processes. SOX transcription factors have diverse tissue-specific expression patterns during early development and have been proposed to act as target-specific transcription factors and/or as chromatin structure regulatory elements. The protein encoded by this gene was identified as a SOX family member based on conserved domains and its expression in various tissues suggests a role in both differentiation and maintenance of several cell types.
Excerpted from Wikipedia’s “SOX12” article, available under the CC BY-SA 4.0 licence.