Structure via PubChem · Public domain (PubChem)
suzetrigine
Sign in to saveAlso known as 4-[(2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl)-4,5-dimethyl-5-(trifluoromethyl)oxolane-2-carboxamido]pyridine-2-carboxamide
Suzetrigine, sold under the brand name Journavx, is an oral medication used for moderate to severe acute pain management in adults. It is a small-molecule non-opioid analgesic that works as a selective inhibitor of Nav1.8-dependent pain-signaling pathways in the peripheral nervous system. Nav1.8 channels are predominantly present in peripheral nociceptive neurons of the dorsal root ganglia. Suzetrigine inhibits pain signals before they reach the central nervous system and has no addictive potential.
Key facts
- Drug.DailyMedID
- Suzetrigine
- Drug.image
- Suzetrigine.svg
- Drug.image_class
- skin-invert-image
- Drug.image2
- Suzetrigine 3D structure.png
- Drug.image_class2
- bg-transparent
- Drug.tradename
- Journavx
- Drug.MedlinePlus
- a625039
- Drug.routes_of_administration
- By mouth
- Drug.class
- Nav1.8 sodium channel blocker; analgesic
- Drug.ATC_prefix
- None
- Drug.legal_US
- Rx-only
- Drug.CAS_number
- 2649467-58-1
- Drug.PubChem
- 156445116
- Drug.DrugBank
- DB18927
- Drug.ChemSpiderID
- 128942439
- Drug.UNII
- LOG73M21H5
- Drug.KEGG
- D12860
- Drug.ChEMBL
- 5314487
via Wikipedia infobox
Chemical data
- Formula
- C21H20F5N3O4
- Molecular weight
- 473.4 g/mol
- IUPAC name
- 4-[[(2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl)-4,5-dimethyl-5-(trifluoromethyl)oxolane-2-carbonyl]amino]pyridine-2-carboxamide
- SMILES
- C[C@H]1[C@H]([C@@H](O[C@@]1(C)C(F)(F)F)C(=O)NC2=CC(=NC=C2)C(=O)N)C3=C(C(=C(C=C3)F)F)OC
- InChIKey
- XSQUJFKRXZMOKA-PAFIKIDNSA-N
- XLogP
- 3
- Polar surface area
- 104 Ų
- H-bond donors
- 2
- H-bond acceptors
- 10
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 3
- Molecule type
- Small molecule
- Indications
- pain, neuralgia, diabetic neuropathy
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Has part
- hydrogen
- Mass
- 473.13739721999997
Show 5 more facts
- isomeric SMILES
- COc1c([C@H]2[C@H](C(=O)Nc3ccnc(C(N)=O)c3)O[C@@](C)(C(F)(F)F)[C@H]2C)ccc(F)c1F
- canonical SMILES
- CC1C(C(OC1(C)C(F)(F)F)C(=O)NC2=CC(=NC=C2)C(=O)N)C3=C(C(=C(C=C3)F)F)OC
- chemical formula
- C₂₁H₂₀F₅N₃O₄
- Commons category
- Suzetrigine
- World Health Organisation international non-proprietary name
- 舒泽曲近
via Wikidata · CC0
~6 min read
Encyclopedic overview
12 sectionsContents
- Medical uses
- Dosage and administration
- Contraindications
- Adverse effects
- Interactions
- Mechanism of action
- History
- Research
- Efficacy
- References
- Further reading
- External links
Suzetrigine, sold under the brand name Journavx, is an oral medication used for moderate to severe acute pain management in adults. It is a small-molecule non-opioid analgesic that works as a selective inhibitor of Nav1.8-dependent pain-signaling pathways in the peripheral nervous system. Nav1.8 channels are predominantly present in peripheral nociceptive neurons of the dorsal root ganglia. Suzetrigine inhibits pain signals before they reach the central nervous system and has no addictive potential.
The most common adverse reactions include itching, muscle spasms, increased blood level of creatine phosphokinase, and rash.
Excerpted from Wikipedia’s “suzetrigine” article, available under the CC BY-SA 4.0 licence.