TCF7
Sign in to saveAlso known as TCF-1, transcription factor 7 (T-cell specific, HMG-box), transcription factor 7
Transcription factor 7 is the gene that in humans encodes for the TCF1 protein.
In the Vinony graph
Within Vinony's link graph, TCF7 is referenced by 813 other articles, and connects out to PubMed, human chromosome 5 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 5.
Its subject is documented across 5 Wikipedia language editions.
Gene data
TCF7- Name
- transcription factor 7
- Type
- protein-coding
- Position
- 134,114,645–134,151,865 (+)
- Aliases
- TCF-1
- Ensembl
- ENSG00000081059
- RefSeq RNA
- NM_001134851.4, NM_001134852.1, NM_001346425.2, NM_001346450.2, NM_001366502.2
- RefSeq protein
- NP_001128323.2, NP_001333354.1, NP_001333379.1, NP_001353431.1, NP_003193.2
This gene encodes a member of the T-cell factor/lymphoid enhancer-binding factor family of high mobility group (HMG) box transcriptional activators. This gene is expressed predominantly in T-cells and plays a critical role in natural killer cell and innate lymphoid cell development. The encoded protein forms a complex with beta-catenin and activates transcription through a Wnt/beta-catenin signaling pathway. Mice with a knockout of this gene are viable and fertile, but display a block in T-lymphocyte differentiation. Alternative splicing results in multiple transcript variants. Naturally-occurring isoforms lacking the N-terminal beta-catenin interaction domain may act as dominant negative regulators of Wnt signaling. [provided by RefSeq, Oct 2016].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
transcription factor 7
- Symbol
- TCF7
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 5:134,114,645-134,151,865
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein TCF7 PDB 2lef.png
Show 7 more facts
- HomoloGene ID
- 135816
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/6932
- genomic start
- 134114681
- chromosome
- human chromosome 5
- genomic end
- 133487556
- cytogenetic location
- 5q31.1
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Transcription factor 7 is the gene that in humans encodes for the TCF1 protein.
==References==
Excerpted from Wikipedia’s “TCF7” article, available under the CC BY-SA 4.0 licence.