KLF7
Sign in to saveAlso known as UKLF, Kruppel-like factor 7 (ubiquitous), Kruppel like factor 7
Kruppel-like factor 7 (ubiquitous), also known as KLF7, is a protein which in humans is encoded by the KLF7 gene.
In the Vinony graph
Vinony's link graph records 814 inbound references to KLF7, and connects out to PubMed, human chromosome 2 and Ensembl genome database project.
Vinony files it under Genes on human chromosome 2 and Transcription factors.
Vinony links it to 6 Wikipedia language editions.
Gene data
KLF7- Name
- KLF transcription factor 7
- Type
- protein-coding
- Position
- 207,074,137–207,173,856 (−)
- Aliases
- UKLF
- Ensembl
- ENSG00000118263
- RefSeq RNA
- NM_001270942.1, NM_001270943.2, NM_001270944.2, NM_001438026.1, NM_003709.4
- RefSeq protein
- NP_001257871.1, NP_001257872.1, NP_001257873.1, NP_001424955.1, NP_003700.1
The protein encoded by this gene is a member of the Kruppel-like transcriptional regulator family. Members in this family regulate cell proliferation, differentiation and survival and contain three C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. A pseudogene of this gene is located on the long arm of chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
KLF transcription factor 7
- Symbol
- KLF7
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:207,074,137-207,173,856
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Research
247 papers- KLF7 regulates super-enhancer-driven IGF2BP2 overexpression to promote the progression of head and neck squamous cell carcinoma.Journal of experimental & clinical cancer research : CR · 2024
- The KLF7/PFKL/ACADL axis modulates cardiac metabolic remodelling during cardiac hypertrophy in male mice.Nature communications · 2023
- HMGB1-mediated elevation of KLF7 facilitates hepatocellular carcinoma progression and metastasis through upregulating TLR4 and PTK2.Theranostics · 2023
- KLF7-regulated ITGA2 as a therapeutic target for inhibiting oral cancer stem cells.Cell death & disease · 2025
- KLF7 orchestrates hippocampal development through neurogenesis and Draxin-mediated neuronal migration.Development (Cambridge, England) · 2025
via PubMed
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 2751
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/8609
- genomic end
- 208031991
- genomic start
- 207938861
- chromosome
- human chromosome 2
- cytogenetic location
- 2q33.3
- expressed in
- testicle
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- References
- Further reading
- External links
Kruppel-like factor 7 (ubiquitous), also known as KLF7, is a protein which in humans is encoded by the KLF7 gene.
This protein is a member of the Kruppel-like family of transcription factors.
Excerpted from Wikipedia’s “KLF7” article, available under the CC BY-SA 4.0 licence.