TGM2

Also known as G-ALPHA-h, GNAH, HEL-S-45, TG2, TGC, TG(C), transglutaminase 2, G(h)

gen de la especie Homo sapiens

In the Vinony graph

Vinony's link graph records 334 inbound references to TGM2, and connects out to celiac disease, PubMed and PubMed Central.

Vinony files it under Autoantigens, EC 2.3.2 and Genes on human chromosome 20.

Vinony links it to 12 Wikipedia language editions.

Gene data

TGM2

Name: transglutaminase 2
Type: protein-coding
Position: 38,127,385–38,168,463 (−)
Aliases: G(h), TG(C), TGC, hTG2, tTG
Ensembl: ENSG00000198959
RefSeq RNA: NM_001323316.2, NM_001323317.2, NM_001323318.2, NM_004613.4, NM_198951.3
RefSeq protein: NP_001310245.1, NP_001310246.1, NP_001310247.1, NP_004604.2, NP_945189.1

Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

chromatin remodeling phospholipase C-activating G protein-coupled receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway extracellular matrix organization negative regulation of endoplasmic reticulum calcium ion concentration negative regulation of endoplasmic reticulum calcium ion concentration regulation of apoptotic process positive regulation of apoptotic process

Molecular function

protein-glutamine gamma-glutamyltransferase activity protein-glutamine gamma-glutamyltransferase activity protein-glutamine gamma-glutamyltransferase activity protein-glutamine gamma-glutamyltransferase activity protein-glutamine gamma-glutamyltransferase activity protein-glutamine gamma-glutamyltransferase activity GTPase activator activity calcium ion binding

Cellular component

chromatin nucleus nucleus nucleus chromosome chromosome mitochondrion mitochondrion

Pathways

Huntington disease - Homo sapiens (human)IL-18 signaling pathway

via MyGene.info

Gene · Ensembl

transglutaminase 2

Symbol: TGM2
Biotype: Protein coding
Organism: Homo sapiens
Location: 20:38,127,385-38,168,463
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Tissue transglutaminase.png

Show 9 more facts

found in taxon: Homo sapiens
HomoloGene ID: 3391
exact match: identifiers.org/ncbigene/7052
genomic end: 36794980
genomic start: 38127385
chromosome: human chromosome 20
Commons category: Tissue transglutaminase
cytogenetic location: 20q11.23
expressed in: decidua

Sources (5)

via Wikidata · CC0

Article · Español

La transglutaminasa tisular (abreviada como TG2 o tTG) es un enzima (número EC: 2.3.2.13) de la familia de las transglutaminasas. Al igual que otras transglutaminasas, une proteínas entre un grupo ε-amino de un residuo de lisina y un grupo γ-carboxamida de un residuo de glutamina, creando un enlace inter- o intramolecular que es altamente resistente a la proteólisis. La tTG es particularmente notable por ser el autoantígeno en la enfermedad celíaca, pero también es conocido por desempeñar un papel en la apoptosis, diferenciación celular y la estabilización de la matriz extracelular. El gen de la tTG humano se encuentra localizada en el cromosoma 20 (20q11.2-q12).

Abstract from DBpedia / Wikipedia · CC BY-SA