Structure via PubChem · Public domain (PubChem)
thenalidine
Sign in to saveAlso known as 1-Methyl-4-amino-N-phenyl-N-(2-thenyl)piperidine, 1-Methyl-4-N-2-thenylanilinopiperidine, Thenophenopiperidine, Thenaldine, Tenalidina, Thenalidinum
Thenalidine is an antihistamine with anticholinergic properties used as an antipruritic drug. It was withdrawn from the US, Canadian, and UK markets in 1963 due to a risk of neutropenia.
Chemical data
- Formula
- C17H22N2S
- Molecular weight
- 286.4 g/mol
- IUPAC name
- 1-methyl-N-phenyl-N-(thiophen-2-ylmethyl)piperidin-4-amine
- SMILES
- CN1CCC(CC1)N(CC2=CC=CS2)C3=CC=CC=C3
- InChIKey
- KLOHYVOVXOUKQI-UHFFFAOYSA-N
- XLogP
- 3.8
- Polar surface area
- 34.7 Ų
- H-bond donors
- 0
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
Withdrawn- Max clinical phase
- Approved
- Molecule type
- Small molecule
- Indications
- Pruritus, allergic disease
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 286.15037
- Has use
- medication
Show 3 more facts
- chemical formula
- C₁₇H₂₂N₂S
- canonical SMILES
- CN1CCC(CC1)N(CC2=CC=CS2)C3=CC=CC=C3
- Commons category
- Thenalidine
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Thenalidine is an antihistamine with anticholinergic properties used as an antipruritic drug. It was withdrawn from the US, Canadian, and UK markets in 1963 due to a risk of neutropenia.
== References ==
Excerpted from Wikipedia’s “thenalidine” article, available under the CC BY-SA 4.0 licence.