Structure via PubChem · Public domain (PubChem)
tiletamine
Sign in to saveTiletamine is a dissociative anesthetic and pharmacologically classified as an NMDA receptor antagonist. It is an arylcyclohexylamine chemically related to ketamine. Tiletamine hydrochloride exists as odorless white crystals.
Key facts
- Drug.Verifiedfields
- changed
- Drug.verifiedrevid
- 470610310
- Drug.IUPAC_name
- 2-Ethylamino-2-(2-thienyl)cyclohexanone
- Drug.image
- Tiletamine structure.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 175px
- Drug.image2
- Tiletamine-ball-and-stick-model.png
- Drug.image_class2
- bg-transparent
- Drug.width2
- 200px
- Drug.alt2
- (S)-tiletamine
- Drug.legal_AU
- S4
- Drug.legal_US
- Schedule III (when combined with Zolazepam)
- Drug.routes_of_administration
- IV, IM, SC, Other
- Drug.metabolism
- Liver
- Drug.excretion
- Kidneys
- Drug.index2_label
- HCl
- Drug.CAS_number
- 14176-49-9
- Drug.CAS_number2
- 14176-50-2
via Wikipedia infobox
Chemical data
- Formula
- C12H17NOS
- Molecular weight
- 223.34 g/mol
- IUPAC name
- 2-(ethylamino)-2-thiophen-2-ylcyclohexan-1-one
- SMILES
- CCNC1(CCCCC1=O)C2=CC=CS2
- InChIKey
- QAXBVGVYDCAVLV-UHFFFAOYSA-N
- XLogP
- 2
- Polar surface area
- 57.3 Ų
- H-bond donors
- 1
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
569 papers- Tiletamine-Zolazepam Use in Exotic Pets and Wildlife Anesthesia: A Narrative Review Towards Practical Guidelines.Animals : an open access journal from MDPI · 2026
- TILETAMINE-ZOLAZEPAM-XYLAZINE ANESTHESIA IN EX SITU BLACK-HANDED SPIDER MONKEYS (ATELES GEOFFROYI SSP.).Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians · 2024
- Dissociative anaesthesia in dogs and cats with use of tiletamine and zolazepam combination. What we already know about it.Polish journal of veterinary sciences · 2021
- Tiletamine-Zolazepam for Total Intravenous Anesthesia in Sheep.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025
- Severe tremors induced by tiletamine e-cigarette and alcohol use: a case report.Frontiers in psychiatry · 2025
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 223.103
Show 3 more facts
- chemical formula
- C₁₂H₁₇NOS
- canonical SMILES
- CCNC1(CCCCC1=O)C2=CC=CS2
- Commons category
- Tiletamine
Sources (2)
via Wikidata · CC0
~2 min read
Encyclopedic overview
4 sectionsContents
- Society and culture
- See also
- References
- External links
Tiletamine is a dissociative anesthetic and pharmacologically classified as an NMDA receptor antagonist. It is an arylcyclohexylamine chemically related to ketamine. Tiletamine hydrochloride exists as odorless white crystals.
It is used in veterinary medicine in the combination product Telazol (tiletamine/zolazepam, 50 mg/ml of each in 5 ml vial) as an injectable anesthetic for use in cats and dogs. It is sometimes used in combination with xylazine (Rompun) to chemically immobilize large mammals such as polar bears and wood bison. Telazol is the only commercially available tiletamine product in the United States. It is contraindicated in patients of an ASA score of III or greater and in animals with CNS signs, hyperthyroidism, cardiac disease, pancreatic or renal disease, pregnancy, glaucoma, or penetrating eye injuries.
Excerpted from Wikipedia’s “tiletamine” article, available under the CC BY-SA 4.0 licence.
Available in 11 languages
via Wikidata sitelinks · CC0