Structure via PubChem · Public domain (PubChem)
triamterene
Sign in to saveAlso known as SK-8542, Triamtereno, Triamterenum, Triamteren, Teridin, Triamtérène, 6-phenylpteridine-2,4,7-triamine
Triamterene (traded under names such as Dyrenium and Dytac) is a potassium-sparing diuretic often used in combination with thiazide diuretics for the treatment of high blood pressure or swelling. The combination with hydrochlorothiazide, is known as hydrochlorothiazide/triamterene.
Key facts
- Drug.Verifiedfields
- changed
- Drug.verifiedrevid
- 470613031
- Drug.IUPAC_name
- 6-phenylpteridine-2,4,7-triamine
- Drug.image
- Triamteren.svg
- Drug.image_class
- skin-invert-image
- Drug.image2
- Triamterene substance photo.jpg
- Drug.tradename
- Dyrenium, others
- Drug.MedlinePlus
- a682337
- Drug.pregnancy_AU
- C
- Drug.pregnancy_US
- C
- Drug.legal_AU
- S4
- Drug.legal_US
- Rx-only
- Drug.legal_UK
- POM
- Drug.routes_of_administration
- By mouth
- Drug.bioavailability
- 30-70%
- Drug.protein_bound
- 67%
- Drug.metabolism
- hydroxylation to para-hydroxytriamterene
- Drug.elimination_half life
- 1-2 hours, active metabolite 3 hours
via Wikipedia infobox
Chemical data
- Formula
- C12H11N7
- Molecular weight
- 253.26 g/mol
- IUPAC name
- 6-phenylpteridine-2,4,7-triamine
- SMILES
- C1=CC=C(C=C1)C2=NC3=C(N=C(N=C3N=C2N)N)N
- InChIKey
- FNYLWPVRPXGIIP-UHFFFAOYSA-N
- XLogP
- 1
- Polar surface area
- 130 Ų
- H-bond donors
- 3
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Research
1,467 papers- Triamterene and the kidney.Nephron · 1989
- Triamterene nephrolithiasis.JAMA · 1980
- Triamterene.The Practitioner · 1963
- Triamterene induces autophagic degradation of lysosome by exacerbating lysosomal integrity.Archives of pharmacal research · 2021
- [Triamterene].Krankenpflege Journal · 1990
via PubMed
~7 min read
Encyclopedic overview
8 sectionsContents
- Side effects
- Caution with certain disease states
- Mechanism of action
- With hydrochlorothiazide
- History
- Research
- References
- External links
Triamterene (traded under names such as Dyrenium and Dytac) is a potassium-sparing diuretic often used in combination with thiazide diuretics for the treatment of high blood pressure or swelling. The combination with hydrochlorothiazide, is known as hydrochlorothiazide/triamterene.
== Side effects == Common side effects may include a depletion of sodium, folic acid, and calcium, nausea, vomiting, diarrhea, headache, dizziness, fatigue, and dry mouth. Serious side effects may include heart palpitations, tingling/numbness, fever, chills, sore throat, rash, and back pain. Triamterene can also cause kidney stones through direct crystallization or by seeding calcium oxalate stones. Triamterene is best avoided in patients with chronic kidney disease due to the possibility of hyperkalemia. People using this drug should use salt substitute cautiously.
Excerpted from Wikipedia’s “triamterene” article, available under the CC BY-SA 4.0 licence.